Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 235
(c) a statistically significant increase in the incidence of exocrine adenomas of the pancreas in both
male and female breeders and offspring; and
(d) an increased incidence, albeit not statistically significant, of pancreatic islet cell carcinomas in females.
On the basis of the results of this study, excessive consumption of regular soft-drinks should be
generally discouraged, in particular for children and adolescents.” (Belpoggi F, and others).
“Aneuploidy has been implicated as an important step leading to various neoplasias... Caffeine induces
aneuploidy through asymmetrical cell division... Most caffeine-treated mitotic cells showed
misalignment of chromosomes at the metaphase plates, and were arrested at prometaphase. Mitotic-arrest
deficient 2 depletion rescued the caffeine-induced delay of mitotic exit, indicating that caffeine-induced
prolongation of mitosis was caused by activation of a mitotic-arrest deficient 2-dependent
spindle checkpoint... Cell division in the presence of caffeine was not symmetrical and resulted in aneuploid
cell production.” (Katsuki Y, and others).
XVI - 39) Cardiac Arrest (primary): “High usual caffeine consumption (> or = 687 mg per day) was
associated with a modestly elevated risk of primary cardiac arrest. The elevated risk associated with
high caffeine consumption appeared to be restricted to never-smokers.” (Weinmann S, and others).
XVI - 40) Cardiac Arrhythmias: Atrial and Ventricular. Fetal tachycardia.
- Atrial: “We present a case of caffeine-induced atrial fibrillation which spontaneously reverted to normal
sinus rhythm. Caffeine is a methylxanthine alkaloid that can cause various supraventricular and
ventricular arrhythmias. It is important to improve public awareness of the potential adverse effects of
high consumption of caffeine-containing products as fatal and serious events can occur.”(Artin B, and
others).
- Ventricular: “Moderate tea intake (< 14 cups per week) during the year prior to infarction is associated
with a lower prevalence, and higher coffee intake (> 14 cups per week) with a slightly higher prevalence,
of ventricular arrhythmias among patients hospitalized with acute myocardial infarction”
(Mukamal K J, and others).
- Fetal tachycardia: “Caffeine ...blocks A1 and A2 adenosine receptors and in high doses inhibits the
phosphodiesterase activity. Caffeine also decreases calcium ion accumulation in the mitochondria of
cardiomyocytes... Caffeine and coffee increase the arterial wall stiffness, blood pressure and endothelium-dependent
flow mediated dilatation. Caffeine also elevates cholesterol and homocysteine blood
level... Acceleration of acute ischemic cardiac disease correlates with high coffee intake... and may induce
intrauterine growth retardation. Due to chronotropic and inotropic activity it may induce fetal tachycardia
and/or extrasystolic beats”. (Dworzanski W, and others).
XVI - 41) Cardiac Impairment of Ventricular Function: “In young healthy subjects,…Caffeine assumption
alone does not exert any acute effect on ventricular long-axis function, but potentiates the
negative effect of cigarette smoking by abolishing right ventricular supernormal response and leading
to a simultaneous impairment in both left ventricular and right ventricular diastolic function.” (Giacomin
E, and others).
XVI - 42) Cardiac underdevelopment and increase in body fat: “Pregnant mice (C57BL/6) were
treated with caffeine (20 mg/kg, i.p.)... This caffeine dose results in a circulating level that is equivalent
to 2 cups of coffee in humans. Exposure to a single dose of caffeine inhibited cardiac ventricular development
by 37% . When offspring were studied in adulthood, we observed that caffeine treatment alone
resulted in a decrease in cardiac function of 38%, as assessed by echocardiography. We also observed a
20% increase in body fat with male mice exposed to caffeine. Exposure to a single dose of caffeine
during embryogenesis results in both short-term effects on cardiac development and long-term effects
on cardiac function.” (Wendler C C, and others).
Is this the cause of the epidemic obesity in children?
XVI - 43) Carpal Tunnel Syndrome: “Overuse of legal drugs (eg, caffeine, nicotine, alcohol) can
contribute to Carpal Tunnel Syndrome and, therefore, should be reduced.” (Ashworth N L).