Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 291
“In 15 subjects after overnight caffeine abstention… caffeinated beverages increased systolic blood
pressure, diastolic blood pressure, and skin conductance and lowered heart rate and skin temperature.
Significant dose-response relationships to caffeine were seen only for systolic blood pressure, heart
rate, and skin temperature. There were significant effects of caffeine on energetic arousal but no consistent
dose-response effects… Caffeinated beverages acutely stimulate the autonomic nervous system
and increase alertness. Although caffeine can exert dose-dependent effects on a number of acute autonomic
responses, caffeine level is not an important factor. Factors besides caffeine may contribute to
these acute effects.” (Quinlan P T, and others).
XVII- 44 -To increase the antinociceptive and antipyretic effects of paracetamol, the acute antiexudative
effect of acetylsalicylic acid and aminophenazone. So, caffeine is used to prevent and medicate
headaches and any other aches, together with other drugs in medications, but this can be equivocal.
The patient medicating with analgesic added with caffeine improves from his aches in few minutes,
but the aches worsen after few hours, needing new doses of caffeine, turning the patient dependent to
it, while present increasing collateral effects from its use.
“While adding caffeine to analgesics increases the number of patients who become free from headache,
it also leads to more patients with nervousness and dizziness”. (Zhang W Y).
“Caffeine increased the analgesic effect of ibuprofen 200 mg, through an earlier onset of analgesic effect.”(McQuay
H J, and others).
XVII- 45 -To medicate respiratory depression in apneic preterm neonates. Is this prematurity
caused by the caffeine drank by the mother? Are these premature neonates with apnea of prematurity
suffering because their withdrawal from the mother’s caffeine, and they depend from caffeine to survive?
The administration of caffeine to preterm neonates has consequences, as seizures, brain cells
death, and persistent changes on respiratory control, besides others:
“Apnea of pre-maturity is common, occurring in 85% of infants born less than 34 week gestation.
Oral caffeine is the most frequent form of therapy. Morphine is used to reduce the pain... We determined
the effect of caffeine and morphine alone and in combination of cell death on the developing
brain of the rat. Cell death… was significantly increased at 12 and 24 hour post-caffeine injection in
the cortex, caudate, nucleus accumbens, hypothalamus, hippocampus and superior colliculus. No alterations
were seen following morphine injection alone. However, in the thalamus, the combination of
caffeine and morphine did increase cell death to a significantly greater extent than caffeine alone.”
(Black A M, and others).
“Caffeine is an adenosine receptor antagonist that is commonly used in the clinic as a respiratory
stimulant to treat apnea of prematurity. (There is) evidence indicating that neonatal caffeine treatment
modifies respiratory control development and that these changes persist until adulthood.... current data
indicate that caffeine treatment, especially during the perinatal period, alters adenosinergic neuromodulation
of the respiratory control system.” (Montandon G, and others).
XVII- 46 -On foals neonates with hypoxic-ischemic encephalopathy: “Doxapram is more effective
than caffeine for rapid correction of hypercapnia in foals with hypoxic-ischemic encephalopathy.”
(Giguère S, and others).
XVII- 47 -To medicate postprandial hypotension.
Coffee, with and without caffeine, promotes the foods digestion, and prevents the postprandial hypnic
effect.
XVII- 48 -To medicate obesity and promote lipolytic action on cellulites.
Caffeine is extensively used as a slimming medication. Drinking caffeine daily, the patient loses fat
but gains small diffuse edemas and many headaches.
“In the 32 cellulite creams tested, Caffeine was present in 14 products, and was the most common
additive, apparently representing an "active" ingredient.” (Sainio E L, and others).