Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 277
“The frequency of migraine headache in a clinic sample of Tourette syndrome subjects was nearly 4fold
more than the frequency of migraines reported in the general population” (Kwak C and others).
XVI - 229) Toxicity exacerbation: “Caffeine exacerbates the acute toxicity of 3,4-methylenedioxymethamphetamine
(MDMA, 'ecstasy') in rats characterized by hyperthermia, tachycardia and lethality.
Co-administration of caffeine with MDMA provoked a switch from MDMA-induced hypothermia and
bradycardia to hyperthermia and tachycardia without influencing MDMA-induced hyperlocomotion.”
(Vanattou-Saifoudine N, and others).
XVI - 230) Type A personality: All patients we had with this personality were plenty with caffeine.
Those who stopped the caffeine became more amiable and sensible, and less provocative.
We conclude that caffeine is the main cause of “type A” personality and this can be changed
stopping the caffeine drinks.
XVI - 231) Umbilical vein endothelial cells inhibition: “These results suggest that high concentrations
of caffeine inhibit cell growth of umbilical vein endothelial cells and induce apoptosis through
the caspase-9 pathway.”(Matsuoka S, and others).
XVI - 232) Urinary hydrogen peroxide levels increased: “A cup of brewed or canned coffee commercially
available in Japan generated 120-420 micro mol hydrogen peroxide in incubation in a neutral
medium at 37 degrees C for 6 h. Apparent hydrogen peroxide levels in urine collected 1-2 h after coffee
drinking increased 3-10-fold compared to the levels before coffee drinking. The major component that
generates hydrogen peroxide is 1,2,4-benzenetriol, and storing urine collected after coffee drinking increased
hydrogen peroxide levels in a time-dependent fashion. Total hydrogen peroxide equivalent
levels excreted in 3 h-urine after coffee drinking were estimated to be 0.5-10% that of coffee consumed.”
(Hiramoto K, and others).
XVI - 233) Urinary incontinence. Unstable bladder. Overactive Bladder Syndrome: “The mean
caffeine intake of women with detrusor instability was significantly higher than that of controls.”
(Arva L A, and others).
“In 65,176 women 37 to 79 years old without incontinence in the Nurses' Health Study and the
Nurses' Health Study II... There was a modest, significantly increased risk of incontinence at least
weekly in women with the highest (greater than 450 mg) daily (caffeine) intake (RR 1.19) and a significant
trend of increasing risk with increasing intake. This risk appeared focused on incident urgency
incontinence (greater than 450 vs less than 150 mg daily, RR 1.34)... The attributable risk of urgency
incontinence associated with high caffeine intake was 25%... A fourth of the cases with the highest caffeine
consumption would be eliminated if high caffeine intake were eliminated.” (Jura Y H, and
others).
“Caffeine at 4.5 mg/kg caused diuresis and decreased the threshold of sensation at filling phase, with
an increase in flow rate and voided volume. So, caffeine can promote early urgency and frequency of
urination. Individuals with lower urinary tract symptom should avoid or be cautious in consuming caffeine
containing foodstuffs.” (Lohsiriwat S, and others).
XVI - 234) Urinary obstruction: “In the 297 women who participated, mean age was 68.2 years,
mean body mass index was 30.2 kg/m(2), and median vaginal parity was 3... Coffee drinking was associated
with difficulty emptying the bladder (adjusted OR 8.6) and weak stream (adjusted OR
5.3).”(Bradley C S, and others).
XVI - 235) Urticaria: “We describe a 10-year-old child who developed urticaria after the intake of
coffee and cola beverages. The prick test and the oral challenge test with caffeine were both positive.”
(Caballero T, and others).
“In a 45-year-old woman with chronic urticaria anaphylactoid reactions occurred after (1) ingestion
of coffee and (2) taking an analgesic drug. Prick testing in the patient and passive cutaneous anaphylax-