Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 167
Scheme IX-2 repeated: Intraocular pressure higher than the smaller Cerebrospinal Fluid pressure
at the other side of the lamina cribosa.
It causes 4 distinct pathophysiologies:
a- It squeezes the Optic Nerve’s disk, causes atrophy of the Optic Nerve’s fibers, increases the disk’s
cup, allows the visibility of the Lamina Cribosa's pores, aches as Migraines and can result in Glaucoma.
b- It squeezes the arterial blood circulation at the Central Retinal Artery and at the Choroids, causing
retinal ischemia, small infarcts seen as small flame hemorrhages or soft exudates, neuronal cells
death, atrophy of retina and choroid, and all of this also results in glaucoma.
c- It squeezes the venous blood circulation, mainly at the arterial-venous crossings and at the border
of the Optic Nerve´s cup, causing the venous blood retention inside the Central Retinal Vein and its
branches, and promotes its thrombosis (occlusion).
d- It increases the spontaneous central retinal venous pulsation.
In “57 eyes of 57 patients with migraine with or without aura... The mean retinal nerve fibre layer
average thickness parameter was found to be thinner in migraine patients. In addition, we found a
strong correlation between migraine severity and retinal nerve fibre layer average thickness parameters.”
(Martinez A, and others).
“Those persons sustaining retinal vein occlusion were older, had higher intraocular pressure, and
were more likely to have definite or probable glaucoma at the baseline examination.” (Klein B E, and
others).
As the intraocular pressure is higher in the supine position (lay down with the belly up) than in sitting
or standing up, most glaucomas worsen when the patient is sleeping.
An intraocular pressure peak causes more glaucoma than a steady pressure rise: “We imaged individual
ganglion cells in isolated rat retinas before and after short hydrostatic pressure increments.
We found that slowly rising pressure to peaks...(50-90 mmHg) did not damage ganglion cells, whereas
a rapid 1 minute pulse to 50 mmHg injured 30% of these cells within 1 hour. The severity of damage
and the number of affected cells increased with stronger or repeated insults.” (Resta V, and others).
As the progressive and definitive damage from any sign or symptom from the Ocular Hypertension is
the Glaucoma, and as it worsens with the increasing age, the Glaucoma is the main definitive sickness
from the Ocular Hypertension Syndrome. Whatever headaches, migraines, variants, other signs or
symptoms the patient feels for 10, 20, 30, or 40 years, provided he lives enough, his ending sickness
probably will be the Glaucoma.
We conclude that the glaucoma is consequent to steady or to occasional intraocular pressure
rise.