Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 234
4. Persistent desire or unsuccessful efforts to cut down or control use.
5. A great deal of time spent in activities necessary to obtain, use, or recover from the effects of the
substance.
6. Important social, occupational, or recreational activities given up or reduced because of substance
use.
7. Continued intake despite knowledge of a persistent or recurrent physical or psychological problem
that is likely to have been caused or exacerbated by the substance.
8. Dependent is the patient that fulfills at least three of the above criteria.
“Although caffeine shares some characteristics with other chemicals of abuse with regard to both
psychological and physiological dependence, important differences exist, especially pertaining to the
action of caffeine in Central Nervous System neurotransmitter systems.” (Suleman A, and Lorenzo N).
“Survey data suggest that 9% to 30% percent of caffeine consumers may be caffeine dependent according
to DSM-IV criteria.”(Griffiths R R, and Chausmer A L).
XVI - 37) “Caffeinism”: The chronic intoxication with caffeine.
“The relative risk of experiencing symptoms for people consuming 240 mg of caffeine (approximately
4-5 cups of coffee or tea) per day (the population average) compared with caffeine abstainers is
1.6 for palpitations, 1.3 for tremor, 1.3 for headache, and 1.4 for insomnia in males and 1.7, 1.5, 1.2
and 1.4 respectively for females.” (Shirlow M J, and Mathers C D).
“Caffeinism usually combines "caffeine dependency" with a wide range of unpleasant physical and
mental conditions including nervousness, irritability, anxiety, tremulousness, muscle twitching (hyper-reflexia),
insomnia, headaches, respiratory alkalosis and heart palpitations. Furthermore, because
caffeine increases the production of stomach acid, high usage over time can lead to peptic ulcers,
erosive esophagitis, and gastro-esophageal reflux disease.” (modified from Wikipedia).
“Medication overuse (combination analgesics and/or an ergotamine-caffeine preparation) headache
is thus associated with (brain) reversible metabolic changes in pain processing structures like other
chronic pain disorders, but also with persistent orbitofrontal hypofunction. The latter is known to occur
in drug dependence and could predispose subgroups of migraineurs to recurrent analgesic overuse.”
(Fumal A, and others).
XVI - 38) Cancers (other) related with caffeine, with its derivatives, and with “Coca-Cola”:
“Caffeidine causes human cancer, possibly through endogenous nitrosation to form mononitroso
caffeidine. Avoiding consumption of salted tea (addition of sodium bicarbonate) or coffee that prevents
the intake of caffeidine will possibly eliminate the risk of mononitroso caffeidine
carcinogenicity.”(Panda G S, and others).
“Caffeine or coffee appears to enhance the frequency with which other carcinogens induce tumors.
Adventists who use coffee are reported to have a greater risk of colon and bladder cancer.
Coffee consumption has been implicated in cancer of the kidney, ovaries, and large bowel, while tea
consumption has been associated with an increased risk of cancer of the rectum.” (Andrews University
Nutrition Department).
“Caffeine and other methylxanthines (theophylline in tea and theobromine in chocolate) have
been suggested as possible risk factors for breast cancer. Methylxanthines have been reported to increase
the severity of fibrocystic breast disease, a benign breast disease, which may increase the
risk of breast cancer.”(Andrews University Nutrition Department).
“Coca-Cola was invented in May 1886 in Atlanta, Georgia by a pharmacist who, by accident or
design, mixed carbonated water with the syrup of sugar, phosphoric acid, caffeine, and other natural
flavors... Coca-Cola is currently sold in more than 200 countries and in early 2000, the company sold
its 10 billionth unit case of Coca-Cola branded products... Its long-term effects when administered as
substitute for drinking water on male and female Sprague-Dawley rats... indicate:
(a) an increase in body weight in all treated animals;
(b) a statistically significant increase of the incidence in females, both breeders and offspring, bearing
malignant mammary tumors;