Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 262
Would it not be easier, cheaper and healthier, to teach all people about not to drink caffeine? Why the
Public Health authorities do not advise the public about the caffeine's bad health consequences? Are the
coffee and caffeinated soft drinks industries' profits more important than the people’s health?
Recently, a big Brazilian industry, Petrobras, set a health campaign between its employees against
soft drinks, and spoke a lot about the health dangers of Phosphoric acid. Not a word against caffeine!
Why?
XVI - 164) Ovarian cancer:
“Tea intake was not associated with ovarian cancer risk in our study population (49,613 Canadian
women). In contrast, a borderline positive association was observed among women who drank > 4 cups
coffee/day compared to women who did not drink coffee”. (Silvera S A, and others).
“Regular coffee drinkers were at significantly increased risk of ovarian cancer compared with women
who did not drink regular coffee.” (Goodman M T, and others).
At Minnesota, Minneapolis, MN, USA, “Laboratory data suggest that caffeine or some components
of coffee may cause DNA mutations and inhibit tumor suppressor mechanisms, leading to neoplastic
growth. This study evaluated the relationship of coffee and caffeine intake with risk of epithelial
ovarian cancer in a prospective cohort study of 29,060 postmenopausal women. An increased risk was
observed in the multivariate model for women who reported drinking five or more cups/day of caffeinated
coffee compared to women who reported drinking none.” (Lueth N A, and others).
“Coffee consumption ... there was a suggested increased risk of ovarian cancer among premenopausal
women in the New England based Case-Control Study of ovarian cancer only and an inverse association
among postmenopausal women. Carrying one or both of the variant CYP19013 A or
CYP19027 G alleles was associated with an 18% increased and 15% decreased (P for trend = 0.05)
risk of ovarian cancer, respectively.” (Kotsopoulos J, and others).
XVI - 165) Pancreatic cancer:
On “Five hundred seventy patients with newly diagnosed pancreatic cancer from 14 Italian centers…
A moderate association, statistically significant only in women (odds ratio, 2.18), was found between
pancreatic cancer and cigarette smoking. Consumption of 1 or 2 cups of coffee per day was not associated
with increased risk; 3 coffees per day increased the risk, but not significantly (odds ratio, 1.49);
with consumption of more than 3 coffees per day the increase in risk was highly significant (odds ratio,
2.53). A statistically significant dose-response relationship was observed in each sex. The association
between coffee use and pancreatic cancer still held after controlling for potential confounding
factors such as cigarette smoking or alcohol use, and when the analysis was restricted to nonsmoking
coffee drinkers.” (Gullo L, and others).
“In Japan... Subjects were 110,792 (46,465 men and 64,327 women) inhabitants… During the followup
period (mean 8.1 years), 225 deaths due to pancreatic cancer were identified. Heavy coffee consumption
(> or =4 cups/day) may increase the risk. Men who reported a history of diabetes mellitus
and women who reported a history of gallstone/cholecystitis were at significantly (2-fold) increased
risk of death from pancreatic cancer.” (Lin Y, and others).
“In Ontario, Canada,...Smoking, BMI, family history of pancreatic cancer, and caffeine were significantly
associated with increased pancreatic cancer risk, while fruit intake and allergies significantly
decreased risk..” (Anderson L N, and others).
XVI - 166) Panic Disorder. Generalized social anxiety disorder. Performance social anxiety disorder.
These are some of the many psychological disturbs that our patients have cured, only stopping
their caffeine drinks, without any medication. It is easy and cheap.
“After a 480-mg caffeine test... A panic attack was induced in 17 (60.7%) panic disorder patients, 4
(16.0%) generalized social anxiety disorder patients, and 10 (52.6%) performance social anxiety disorder
patients, during the caffeine test. There is an association between panic disorder and performance
social anxiety disorder hyperreactivity to an oral caffeine challenge test.” (Nardi A E, and others).
XVI - 167) Paraproteinemias? They have some characteristics of the chronic caffeine poisoning.