Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 254
XVI - 130) Leukemia (acute) in children. At France, “...comparing 472 (407 acute lymphoblastic
leukaemia and 62 acute myeloblastic leukaemia) cases of childhood acute leukaemia... Maternal alcohol
consumption of more than 1 drink per day was related to acute lymphoblastic leukaemia (OR =
2.8). While maternal coffee consumption was not significantly related to acute leukaemia (OR = 1.4),
highest intake of coffee (more than 3 cups per day) during pregnancy was associated with acute
leukaemia in children whose mothers were non-smokers (OR = 1.9)”. (Menegaux F, and others).
XVI - 131) Liver enzymes reduced. “In coffee drinkers, liver enzymes (gamma-glutamyl transferase,
alanine-amino transferase, and alkaline phosphatase) and serum bilirubin were lower than in non-coffee-drinking
subjects or in those consuming less than 3 cups daily.” (Casiglia E, and others).
XVI - 132) Liver toxicity potentiation, acute damage exacerbated, and pro-inflammatory cytokines
increased:
“Caffeine triples the amount of a toxin called N-acetyl-p-benzoquinone imine produced by the enzyme
as it breaks down acetaminophen (paracetamol) (73 trade-marks on Brazil). This same toxin is
also produced during an interaction between alcohol and acetaminophen that's also well known to damage
the liver. Some people may be more vulnerable to this toxic interaction than others. They might include
people who take certain antiepileptic medications, such as carbamazepine and Phenobarbital, and
people who use the alternative remedy St. John's Wort.” (Nelson S).
“It is shown that caffeine at lower doses (10 and 20 mg/kg) strongly exacerbated acute liver damage
and increased levels of proinflammatory cytokines. Caffeine administration exacerbated liver damage
even when mice consumed caffeine chronically, although the extent of exacerbation was less than in
"naive" mice that did not consume caffeine before.” (Ohta A, and others).
“Cotreatment of rats with a low hepatotoxic dose (30.7 mg/kg, i.p.) of allyl alcohol and a higher, but
nontoxic, dose (150 mg/kg, oral) of caffeine potentiated the hepatotoxicity of allyl alcohol. The depression
of hepatic nonprotein sulfhydryls... was much more severe than that caused by allyl alcohol or caffeine
alone and appeared as early as 30 minutes after administration. The production of melondialdehyde
in the rat liver was significantly higher... Severe liver damage induced by cotreatment with caffeine
and allyl alcohol was further, markedly enhanced by phenobarbital pretreatment (80 mg/kg, i.p., 3
days)... Thus, extensive necrosis of periportal hepatocytes was noted, as well as edema and accumulation
of inflammatory cells in the necrotic foci.” (Karas M, and Chakrabarti S K).
XVI - 133) Low-density lipoprotein cholesterol (LDL) higher level: “Higher caffeinated beverage
intake was associated with higher low-density lipoprotein cholesterol levels and a higher ratio of total
to high-density lipoprotein cholesterol, both indicative of greater coronary disease risk.” (Lane J D, and
others).
XVI - 134) Lower mental well-being: In Brisbane, Australia, “We investigated the temporal relationship
between lifestyle and mental health among 564 midlife women. The mental health measured included
anxiety, depression, and mental well-being; the lifestyle measures included body mass index
(BMI), exercise, smoking, alcohol use, and caffeine consumption. We found that BMI was positively
related with mental well-being; smokers had lower mental well-being than nonsmokers, and noncaffeine
drinkers had higher mental well-being.” (Xu Q, and others).
XVI - 135) Lung adenocarcinoma: