Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 285
XVII- 9 - Retinal neuronal death atenuation: Orally administrated epigallocatechin gallate attenuates
injury to the retina caused by ischemia/reperfusion where caspases were activated….it was shown
that white light-induced apoptosis is caspase-independent and can be blunted by epigallocatechin gallate.”(Zhang
B, and others).
XVII- 10 - Serum uric acid and hyperuricemia lowering: “Coffee consumption is associated with
lower serum uric acid level and hyperuricemia frequency, but tea consumption is not. Total caffeine
from coffee and other beverages and tea intake were not associated with serum uric acid levels The inverse
association with coffee appears to be via components of coffee other than caffeine.”(Choi H K,
and Curham G).
B – Caffeine alone, caffeine benzoate, and caffeinated coffee, tea and colas: Their effect can be
caused by the caffeine alone, or by its sum up with the decaffeinated ones:
XVII- 11 - Alzheimer's disease therapy: ''Acute caffeine administration to both young adult and aged
Alzheimer's disease transgenic mice... both plasma and brain Abeta levels are reduced by acute or
chronic caffeine administration in several Alzheimer's disease transgenic lines and ages, indicating a
therapeutic value of caffeine against Alzheimer's disease''. (Cao C, and others).
XVII- 12 - Cardiovascular mortality reduction for older people:
Only for those caffeine resistant people that did not present any serious damage from it until the age
of 65 years, and without arterial hypertension, caffeine drinks may reduce only the cardiovascular disease
mortality (Greenberg J A, and others). No significant protective effect was found in participants
before 65 year-old, or in cerebrovascular disease mortality at any age.
To Japanese people between 40 and 79 year-old, “Green tea consumption is associated with reduced
mortality due to cardiovascular disease.” (Kuriyama S, and others). Their statistics show that those Japanese,
who have higher consumption of green tea, also have smaller consumption of coffee. As green
tea has less caffeine than coffee, maybe the smaller daily intake of caffeine by those people caused
those results. The same people higher consumer of green tea had an increase of gastric and lung cancer
in men, and lung and colorectal cancer in women, wich the authors did not comment.
In 817 men and women with more than 70-year-old, living in northern Finland, “the total mortality
rate was inversely related to the number of cups (average volume, 125 ml) of coffee consumed daily.”
(Happonen P, and others).
“In Saudi Arabia... Of the 3,430 men and women aged 30-70 years... 6.3% were classified as having
indications of coronary heart disease. Those who did drink more than 6 cups of black tea (>480 ml)
per day had a significantly lower prevalence of coronary heart disease than the nontea drinkers (OR =
0.49). There was a positive dose-response effect between tea consumption and coronary heart disease
that was persistent after adjustment for various risk factors.” (Hakim I A, and others).
XVII- 13 -Cognitive decline reduction: Only “women (aged 65 years and over) with high rates of caffeine
consumption (over three cups per day) showed less decline in verbal retrieval, and to a lesser extent
in visuospatial memory over 4 years than women consuming one cup or less.” (Ritchie K, and others).
Between “1003 Japanese subjects aged > or =70 y…A higher consumption of green tea is associated
with a lower prevalence of cognitive impairment in humans.” Smaller benefit was found for black
or oolong tea, and no benefit for coffee. (Kuriyama S, and others).
Meanwhile, there is the opposite: On “923 healthy adults from the Lothian Birth Cohort 1936 Study,
on whom there were intelligence quotient (IQ) data from age 11 years... Higher cognitive scores were
associated with coffee consumption, and lower cognitive scores with tea consumption, but these effects
were not significant in the fully adjusted model... The results suggest that the significant caffeine intake-cognitive
ability associations are bidirectional-because childhood IQ and estimated prior IQ are
associated with the type of caffeine intake in old age-and partly confounded by social class.”(Corley J,
and others).