Clinician's Pocket Drug Reference 2008

Digoxin 79250–500 mg qid Peds 6 mo:5 mg/dose tid–qid. Children: 10 mg/dose tid–qid Caution: [B, –] Contra: Infants< 6 mo, NAG, MyG, severe UC, BOO Disp: Caps 10, 20 mg; tabs 20 mg; syrup 10mg/5 mL; inj 10 mg/mL SE: Anticholinergic SEs may limit dose Notes: Take30–60 min before meal; avoid EtOH, do not administer IVDidanosine [ddI] (Videx) WARNING: Allergy manifested as fever,rash, fatigue, GI/resp Sxs reported; stop drug immediately & do not rechallenge;lactic acidosis & hepatomegaly/steatosis reported Uses: *HIV Infxn in zidovudineintolerantpts* Action: NRTI Dose: Adults. > 60 kg: 400 mg/d PO or 200 mg PObid. < 60 kg: 250 mg/d PO or 125 mg PO bid; adults should take 2 tabs/administration.Peds. 2 wks to 8 mo age 100 mg/m 2 , > 8 mo 120 mg/m 2 PO BID; ↓ in renalimpair Caution: [B, –] CDC recommends HIV-infected mothers not breast-feedContra: Component sensitivity Disp: Chew tabs 25, 50, 100, 150, 200 mg; powderpackets 100, 167, 250, 375 mg; powder for soln 2, 4 g SE: Pancreatitis, peripheralneuropathy, D, HA Notes: Do not take w/ meals; thoroughly chew tablets, do notmix w/ fruit juice or acidic beverages; reconstitute powder w/ H 2 O, many drug interactionsDiflunisal (Dolobid) WARNING: May ↑ risk of cardiovascular events &GI bleeding Uses: *Mild–moderate pain; osteoarthritis* Action: NSAID Dose:Pain: 500 mg PO bid. Osteoarthritis: 500–1500 mg PO in 2–3 ÷ doses; ↓ in renalimpair, take w/ food/milk Caution: [C (D 3rd tri or near delivery), ?] CHF, HTN,renal/hepatic dysfunction, & Hx PUD. Contra: Allergy to NSAIDs or aspirin, activeGI bleed Disp: Tabs 250, 500 mg SE: May ↑ bleeding time; HA, abd cramps,heartburn, GI ulceration, rash, interstitial nephritis, fluid retentionDigoxin (Lanoxin, Lanoxicaps, Digitek) Uses: *CHF, AF & flutter,& PAT* Action: Positive inotrope; ↑ AV node refractory period Dose: Adults. POdigitalization: 0.5–0.75 mg PO, then 0.25 mg PO q6–8h to total 1–1.5 mg. IV orIM digitalization: 0.25–0.5 mg IM or IV, then 0.25 mg q4–6h to total 0.125–0.5mg/d PO, IM, or IV (average daily dose 0.125–0.25 mg). Peds. Preterm infants:Digitalization: 30 mcg/kg PO or 25 mcg/kg IV; give 1/2 of dose initial, then 1/4 ofdose at 8–12-h intervals for 2 doses. Maint: 5–7.5 mcg/kg/24 h PO or 4–6 mcg/kg/24 h IV ÷ q12h. Term infants: Digitalization: 25–35 mcg/kg PO or 20–30mcg/kg IV; give 1⁄2 the initial dose, then 1⁄3 of dose at 8–12 h. Maint: 6–10mcg/kg/24 h PO or 5–8 mcg/kg/24 h ÷ q12h. 1 mo–2 y: Digitalization: 35–60mcg/kg PO or 30–50 mcg/kg IV; give 1/2 the initial dose, then 1/3 dose at 8–12-hintervals for 2 doses. Maint: 10–15 mcg/kg/24 h PO or 7.5–15 mcg/kg/24 h IV ÷q12h. 2–10 y: Digitalization: 30–40 mcg/kg PO or 25 mcg/kg IV; give 1 ⁄2 initial