Clinician's Pocket Drug Reference 2008

116 Hydrocodone & Aspirinnonnarcotic analgesic Dose: Adult: 1–2 caps or tabs PO q4–6h PRN; soln 15 mL Q4-6H Peds: soln (Hycet) 0.27 mL/kg Q 4-6 h Caution: [C, M] Contra: CNSdepression, severe resp depression Disp: Many formulations; specify hydrocodone/APAPdose; caps 5/500; tabs 2.5/500, 5/325, 5/400, 5/500, 7.5/325,7.5/400, 7.5/500, 7.5/650, 7.5/750, 10/325, 10/400, 10/500, 10/650, 10/660,10/750; soln Hycet (fruit punch) (7.5 mg hydrocodone/325 mg acetaminophen /15mL SE: GI upset, sedation, fatigue Notes: Do not exceed > 4 g APAP/dHydrocodone & Aspirin (Lortab ASA, others) [C-III] Uses:*Moderate–severe pain* Action: Narcotic analgesic with NSAID Dose: 1–2 POq4–6h PRN, w/ food/milk Caution: [C, M] ↓ renal Fxn, gastritis/PUD, Contra:Component sensitivity; children w/chickenpox (Reye’s synd) Disp: 5 mg hydrocodone/500mg ASA/tab SE: GI upset, sedation, fatigue Notes: Monitor for GIbleedHydrocodone & Guaifenesin (Hycotuss Expectorant, others)[C-III] Uses: *Nonproductive cough* associated with resp Infxn Action:Expectorant w/ cough suppressant Dose: Adults & Peds >12 y. 5 mL q4h pc & hs.Peds. < 2 y: 0.3 mg/kg/d ÷ qid. 2–12 y: 2.5 mL q4h pc & hs Caution: [C, M] Contra:Component sensitivity Disp: Hydrocodone 5 mg/guaifenesin 100 mg/5 mLSE: GI upset, sedation, fatigueHydrocodone & Homatropine (Hycodan, Hydromet, others)[C-III] Uses: *Relief of cough* Action: Combo antitussive Dose: (Based on hydrocodone)Adults. 5–10 mg q4–6h. Peds. 0.6 mg/kg/d ÷ tid–qid Caution: [C, M]Contra: NAG, ↑ ICP, depressed ventilation Disp: Syrup 5 mg hydrocodone/5 mL;tabs 5 mg hydrocodone SE: Sedation, fatigue, GI upset Notes: Do not give < q4h;see individual drugsHydrocodone & Ibuprofen (Vicoprofen) [C-III] Uses: *Moderate–severepain (< 10 d)* Action: Narcotic w/ NSAID Dose: 1–2 tabs q4–6h PRNCaution: [C, M] Renal insuff; ↓ effect w/ ACE inhibitors & diuretics; ↑ effect w/CNS depressants, EtOH, MAOI, aspirin, TCA, anticoagulants Contra: Componentsensitivity Disp: Tabs 7.5 mg hydrocodone/200 mg ibuprofen, SE: Sedation, fatigue,GI upsetHydrocodone & Pseudoephedrine (Detussin, Histussin-D,others) [C-III] Uses: *Cough & nasal congestion* Action: Narcotic coughsuppressant with decongestant Dose: 5 mL qid, PRN Caution: [C, M] Contra:MAOIs Disp: hydrocodone/pseudoephedrine 5 mg /60 mg , 3 mg/15 mg 5 mL; tab5 mg/60 mg SE: ↑ BP, GI upset, sedation, fatigueHydrocodone, Chlorpheniramine, Phenylephrine, Acetaminophen,& Caffeine (Hycomine Compound) [C-III] Uses:*Cough & Sxs of URI* Action: Narcotic cough suppressant w/ decongestants &analgesic Dose: 1 tab PO q4h PRN Caution: [C, M] Contra: NAG Disp: Hydrocodone5 mg/chlorpheniramine 2 mg/phenylephrine 10 mg/APAP 250 mg/caffeine30 mg/tab SE: ↑ BP, GI upset, sedation, fatigue