Clinician's Pocket Drug Reference 2008

102 Ferrous Gluconate ComplexFerrous Gluconate Complex (Ferrlecit) Uses: *Iron deficiency anemiaor supl to erythropoietin therapy* Action: Fe Supl Dose: Test dose: 2 mL (25mg Fe) IV over 1 h, if OK, 125 mg (10 mL) IV over 1 h. Usual cumulative dose 1 gFe over 8 sessions (until favorable Hct) Caution: [B, ?] Contra: non-Fedeficiencyanemia; CHF; Fe overload Disp: Inj 12.5 mg/mL Fe SE: ↓ BP, seriousallergic Rxns, GI disturbance, inj site Rxn Notes: Dose expressed as mg Fe; mayinfuse during dialysisFerrous Sulfate (OTC) Uses: *Fe deficiency anemia & Fe supl* Action:Dietary supl Dose: Adults. 100–200 mg elemental Fe/d in ÷ doses. Peds. 1–6mg/kg/d ÷ daily–tid; on empty stomach (OK w/ meals if GI upset occurs); avoidantacids Caution: [A, ?] ↑ absorption w/ vitamin C; ↓ absorption w/ tetracycline,fluoroquinolones, antacids, H 2 -blockers, proton pump inhibitors Contra: Hemochromatosis,hemolytic anemia Disp: Tabs 187 (60 mg Fe), 200 (65 mg Fe),324 (65 mg Fe), 325 mg (65 mg Fe); SR caplets & tabs 160 mg (50 mg Fe), 200mg (65 mg Fe); gtt 75 mg/0.6 mL (15 mg Fe/0.6 mL); elixir 220 mg/5 mL (44 mgFe/5 mL); syrup 90 mg/5 mL (18 mg Fe/5 mL) SE: GI upset, constipation, darkstools, discolored urineFexofenadine (Allegra, Allegra-D) Uses: *Allergic rhinitis* Action:Selective antihistamine, antagonizes H1 receptors Dose: Adults & Peds >12 y. 60mg PO bid or 180 mg/d; ↓ in renal impair Caution: [C, ?] w/nevirapine Contra:Component sensitivity Disp: Caps 60 mg; tabs 30, 60, 180 mg; Susp 6 mg/mL;Allegra-D (60 mg fexofenadine/120 mg pseudoephedrine) SE: Drowsiness (rare), HAFilgrastim [G-CSF] (Neupogen) Uses: *↓ incidence of Infxn in febrileneutropenic pts; Rx chronic neutropenia* Action: Recombinant G-CSF Dose:Adults & Peds. 5 mcg/kg/d SQ or IV single daily dose; D/C when ANC >10,000Caution: [C, ?] w/ drugs that potentiate release of neutrophils (eg, lithium) Contra:Allergy to E. coli-derived proteins or G-CSF Disp: Inj 300, 600 mcg/mL SE:Fever, alopecia, N/V/D, splenomegaly, bone pain, HA, rash Notes: CBC & plt;monitor for cardiac events; no benefit w/ ANC >10,000/mm 3Finasteride (Proscar, Propecia) Uses: *BPH & androgeneticalopecia* Action: ↓ 5α-Reductase Dose: BPH: 5 mg/d PO. Alopecia: 1 mg/d PO;food may ↓ absorption Caution: [X, –] Hepatic impair Contra: Pregnant womenshould avoid handling pills, teratogen to male fetus Disp: Tabs 1 mg (Propecia),5 mg (Proscar) SE: ↓ libido, volume ejaculate, ED, gynecomastia Notes: ↓ PSAby ~50%; reestablish PSA baseline 6 mo (double PSA for “true” reading; 3–6 mofor effect on urinary Sxs; continue to maintain new hair, not for use in womenFlavoxate (Urispas) Uses: *Relief of Sx of dysuria, urgency, nocturia,suprapubic pain, urinary frequency, incontinence* Action: Antispasmodic Dose:100–200 mg PO tid–qid Caution: [B, ?] Contra: GI obst, GI hemorrhage, ileus,achalasia, BPH Disp: Tabs 100 mg SE: Drowsiness, blurred vision, xerostomiaFlecainide (Tambocor) WARNING: ↑ mortality in patients with ventriculararrhythmias and recent MI; pulmonary effects reported; pro-ventricular effects