Clinician's Pocket Drug Reference 2008

Hydrocodone & Acetaminophen 115pheresis: 250–700 mL; ↓ in renal failure Caution: [C, +] Contra: Severe bleedingdisorders, CHF, oliguric/anuric renal failure Disp: Inj 6 g/100 mL SE: Bleeding(↑ PT, PTT, bleed time) Notes: Not blood or plasma substituteHuman Papillomavirus (Types 6,11,16,18) RecombinantVaccine (Gardasil) Uses: *Prevent cervical CA, precancerous genital lesions,and genital warts due to HPV types 6, 11, 16, 18 in females 9–26 yrs* Action:Recombinant vaccine, passive humoral immunity Dose: 0.5 mL IM initial,then 2 and 6 mo Caution: [B, ?/–] Disp: Single-dose vial and prefilled syringe: 0.5ml SE: Site Rxn (pain, erythema, swelling, pruritus), fever Notes: First approvedcancer prevention vaccine; report adverse events to VAERS 1-800-822-7967.Hydralazine (Apresoline, others) Uses: *Moderate–severe HTN;CHF* (w/ Isordil) Action: Peripheral vasodilator Dose: Adults. Initial 10 mg POqid, ↑ to 25 mg qid 300 mg/d max. Peds. 0.75–3 mg/kg/24 h PO ÷ q6–12h; ↓ inrenal impair; CBC & ANA before Caution: [C, +] ↓ hepatic Fxn & CAD; ↑ toxw/ MAOI, indomethacin, β-blockers Contra: Dissecting aortic aneurysm, mitralvalve/rheumatic heart Dz Disp: Tabs 10, 25, 50, 100 mg; inj 20 mg/mL SE: SLElikesynd w/ chronic high doses; SVT following IM route, peripheral neuropathyNotes: Compensatory sinus tachycardia eliminated w/ β-blockerHydrochlorothiazide (HydroDIURIL, Esidrix, others) Uses:*Edema, HTN* Action: Thiazide diuretic; ↓ distal tubule Na reabsorption Dose:Adults. 25–100 mg/d PO single or ÷ doses. Peds. < 6 mo: 2–3 mg/kg/d in 2 ÷doses. > 6 mo: 2 mg/kg/d in 2 ÷ doses Caution: [D, +] Contra: Anuria, sulfonamideallergy, renal insuff Disp: Tabs 25, 50, mg; caps 12.5 mg; PO soln 50 mg/5mL SE: ↓ K + , hyperglycemia, hyperuricemia, ↓ Na + ; sun sensitivityHydrochlorothiazide & Amiloride (Moduretic) Uses: *HTN*Action: Combined thiazide & K + -sparing diuretic Dose: 1–2 tabs/d PO Caution:[D, ?] Contra: Renal failure, sulfonamide allergy Disp: Tabs (amiloride/HCTZ)5 mg/50 mg SE: ↓ BP, photosens, ↑ K + /↓ K + , hyperglycemia, ↓ Na + , hyperlipidemia,hyperuricemiaHydrochlorothiazide & Spironolactone (Aldactazide) Uses:*Edema, HTN* Action: Thiazide & K + -sparing diuretic Dose: 25–200 mg eachcomponent/d, ÷ doses Caution: [D, +] Contra: Sulfonamide allergy Disp: Tabs(HCTZ/spironolactone) 25 mg/25 mg, 50 mg/50 mg SE: Photosens, ↓ BP, ↑ or↓ K + , ↓ Na + , hyperglycemia, hyperlipidemia, hyperuricemiaHydrochlorothiazide & Triamterene (Dyazide, Maxzide)Uses: *Edema & HTN* Action: Combo thiazide & K + -sparing diuretic Dose:Dyazide: 1–2 caps PO daily–bid. Maxzide: 1 tab/d PO Caution: [D, +/–] Contra:Sulfonamide allergy Disp: (Triamterene/HCTZ) 37.5 mg/25 mg, 75 mg/50 mg SE:Photosens, ↓ BP, ↑ or ↓ K + , ↓ Na + , hyperglycemia, hyperlipidemia, hyperuricemiaNotes: HCTZ component in Maxzide more bioavailable than in DyazideHydrocodone & Acetaminophen (Lorcet, Vicodin, Hycet,others) [C-III] Uses: *Moderate–severe pain*; Action: Narcotic analgesic w/