Clinician's Pocket Drug Reference 2008

Ticarcillin/Potassium Clavulante 201[D, –] Contra: Resistance to mercaptopurine Disp: Tabs 40 mg SE: ↓ BM (leucopenia/thrombocytopenia),N/V/D, anorexia, stomatitis, rash, hyperuricemia, rarehepatotoxThioridazine (Mellaril) WARNING: Dose-related QT prolongationUses: *Schizophrenia,* psychosis Action: Phenothiazine antipsychotic Dose:Adults. Initial, 50–100 mg PO tid; maint 200–800 mg/24 h PO in 2–4 ÷ doses.Peds > 2 y. 0.5–3 mg/kg/24 h PO in 2–3 ÷ doses Caution: [C, ?] Phenothiazines,QT c -prolonging agents, aluminum Contra: Phenothiazine sensitivity Disp: Tabs10, 15, 25, 50, 100, 150, 200 mg; PO conc 30, 100 mg/mL; SE: Low incidence ofEPS; ventricular arrhythmias; ↓ BP, dizziness, drowsiness, neuroleptic malignantsynd, Szs, skin discoloration, photosens, constipation, sexual dysfunction, blooddyscrasias, pigmentary retinopathy, hepatic impair Notes: Avoid EtOH, dilute POconc in 2–4 oz liqThiothixene (Navane) Uses: *Psychotic disorders* Action: AntipsychoticDose: Adults & Peds > 12 y. Mild–moderate psychosis: 2 mg PO tid, up to20–30 mg/d. Severe psychosis: 5 mg PO bid; ↑ to max of 60 mg/24 h PRN. IMuse: 16–20 mg/24 h ÷ bid–qid; max 30 mg/d. Peds < 12 y. 0.25 mg/kg/24 h PO ÷q6–12h Caution: [C, ?] Contra: Phenothiazine sensitivity Disp: Caps 1, 2, 5, 10,20 mg; PO conc 5 mg/mL; inj 10 mg/mL SE: Drowsiness, EPS most common; ↓BP, dizziness, drowsiness, neuroleptic malignant synd, Szs, skin discoloration,photosens, constipation, sexual dysfunction, blood dyscrasias, pigmentaryretinopathy, hepatic impair Notes: Dilute PO conc immediately before useTiagabine (Gabitril) Uses: *Adjunct in partial Szs,* bipolar disorder Action:Inhibition of GABA Dose: Adults & Peds ≥ 12 y. Initial 4 mg/d PO, ↑ by 4mg during 2nd wk; ↑ PRN by 4–8 mg/d based on response, 56 mg/d max; w/foodCaution: [C, M] Contra: Component allergy Disp: Tabs 2, 4, 12, 16 , 20 mg SE:Dizziness, HA, somnolence, memory impair, tremors Notes: Use gradual withdrawal;used in combo w/ other anticonvulsantsTicarcillin (Ticar) Uses: Infxns due to gram(–) bacteria (Klebsiella, Proteus,E. coli, Enterobacter, P. aeruginosa, & Serratia) involving the skin, bone, resp &urinary tract, abdomen, sepsis Action: 4th-gen PCN, bactericidal; ↓ cell wallsynth. Spectrum: Some gram (+) (strep, fair enterococcus, not MRSA), gram(–)enhanced w/aminoglycoside use; good anaerobes (Bacteroides) Dose: Adults. 3 gIV q4–6h. Peds. 200–300 mg/kg/d IV ÷ q4–6h; ↓ w/in renal insuff failure Caution:[B, +] PCN sensitivity, renal impair, Sz hx, Na restriction Contra: Allergy toclass Disp: Inj 1, 3, 6, 20, 30 g SE: Interstitial nephritis, anaphylaxis, bleeding,rash, hemolytic anemia Notes: Used in combo w/ aminoglycosidesTicarcillin/Potassium Clavulanate (Timentin) Uses: *Infxns ofthe skin, bone, resp & urinary tract, abdomen, sepsis * Action: 4th-gen PCN; bactericidal;↓ cell wall synth; clavulanic acid blocks β-lactamase. Spectrum: Goodgram (+), not MRSA; good gram(–) & anaerobes Dose: Adults. 3.1 g IV q4–6h.Peds. 200–300 mg/kg/d IV ÷ q4–6h; ↓ in renal failure Caution: [B, +/–] PCN