Clinician's Pocket Drug Reference 2008

166 PemirolastBM impair Contra: Component sensitivity Disp: 500-mg vial SE: Neutropenia,thrombocytopenia, N/V/D, anorexia, stomatitis, renal failure, neuropathy, fever, fatigue,mood changes, dyspnea, anaphylactic Rxns Notes: Avoid NSAIDs, followCBC/plateletsPemirolast (Alamast) Uses: *Allergic conjunctivitis* Action: Mast cellstabilizer Dose: 1–2 gtt in each eye qid Caution: [C, ?/–] Disp: 0.1% (1 mg/ml) in10-mL bottles SE: HA, rhinitis, cold/flu symptoms, local irritation Notes: Wait 10min before inserting contactsPenbutolol (Levatol) Uses: *HTN* Action: β-adrenergic receptorblocker, β 1 , β 2 Dose: 20–40 mg/d; ↓ in hepatic insuff Caution: [C 1st tri; D if2nd/3rd tri, M] Contra: Asthma, cardiogenic shock, cardiac failure, heart block,bradycardia, COPD, pulm edema Disp: Tabs 20 mg SE: Flushing, ↓ BP, fatigue,hyperglycemia, GI upset, sexual dysfunction, bronchospasmPenciclovir (Denavir) Uses: *Herpes simplex (herpes labialis/cold sores)*Action: Competitive inhibitor of DNA polymerase Dose: Apply at 1st sign of lesions,then q2h while awake × 4 d Caution: [B, ?/–] Contra: Allergy, previousRxn to famiciclovir Disp: Cream 1% [OTC] SE: Erythema, HA Notes: Do notapply to mucous membranesPenicillin G, Aqueous (Potassium or Sodium) (Pfizerpen,Pentids) Uses: *Bacteremia, endocarditis, pericarditis, resp tract Infxns,meningitis, neurosyphilis, skin/skin structure Infxns* Action: Bactericidal; ↓ cellwall synth. Spectrum: Most gram (+) (not staphylococci), streptococci, N. meningitidis,syphilis, clostridia, & anaerobes (not Bacteroides) Dose: Adults.400,000–800,000 units PO qid; IV doses vary depending on indications; range0.6–24 million units/d in ÷ doses q4h. Peds. Newborns