Clinician's Pocket Drug Reference 2008

Clozapine 67Clopidogrel (Plavix) Uses: *Reduce atherosclerotic events*, administerASAP in ECC setting w/ high risk ST depression or T wave inversion Action: ↓Plt aggregation Dose: 75 mg/d; 300-600 mg PO × 1 dose can be used to load pts;300 mg PO, then 75 mg Daily 1–9 mo (ECC 2005) Caution: [B, ?] Active bleeding;risk of bleeding from trauma & other; TTP; liver Dz Contra: Coagulation disorders,active/or intracranial bleeding; CABG planned w/in 5–7 days Disp: Tabs75 mg SE: ↑ bleeding time, GI intolerance, HA, dizziness, rash, thrombocytopenia,↓ WBC Notes: Plt aggregation to baseline ≈ 5 days after D/C, plt transfusionto reverse acutelyClorazepate (Tranxene) [C-IV] Uses: *Acute anxiety disorders, acuteEtOH withdrawal Sxs, adjunctive therapy in partial Szs* Action: Benzodiazepine;antianxiety agent Dose: Adults. 15–60 mg/d PO single or ÷ doses. Elderly & debilitatedpts: Initial 7.5–15 mg/d in ÷ doses. EtOH withdrawal: Day 1: Initial 30 mg;then 30–60 mg ÷ doses; Day 2: 45–90 mg ÷ doses; Day 3: 22.5–45 mg ÷ doses; Day4: 15–30 mg ÷ doses. Peds. 3.75–7.5 mg/dose bid to 60 mg/d max ÷ bid-tid Caution:[D, ?/–] Elderly; Hx depression Contra: NAG; Not OK