Clinician's Pocket Drug Reference 2008

Omega-3 fatty acid 157dostatin LAR (depot): 10–30 mg IM q4wk Peds. 1–10 mcg/kg/24 h SQ in 2–4 ÷doses. Caution: [B, +] Hepatic/renal impair Disp: Inj 0.05, 0.1, 0.2, 0.5, 1 mg/mL;10, 20, 30 mg/5 mL LAR depot SE: N/V, abd discomfort, flushing, edema, fatigue,cholelithiasis, hyper/hypoglycemia, hepatitisOfloxacin (Floxin, Ocuflox Ophthalmic) Uses: *Lower resp tract,skin & skin structure, & UTI, prostatitis, uncomplicated gonorrhea, & ChlamydiaInfxns; topical (bacterial conjunctivitis; otitis externa; if perforated ear drum > 12 y)*Action: Bactericidal; ↓ DNA gyrase. Broad spectrum gram (+) & (–): S. pneumoniae,S. aureus, S. pyogenes, H. influenzae, P. mirabilis, N. gonorrhoeae, C. trachomatis,E. coli Dose: Adults. 200–400 mg PO bid or IV q12h. Adults & Peds>1 y. Ophth: 1–2 gtt in eye(s) q2–4h for 2 d, then qid × 5 more d. Adults & Peds> 12 y. Otic: 10 gtt in ear(s) bid for 10 d. Peds 1–12 y. Otic: 5 gtt in ear(s) for 10 d.↓ in renal impair, take on empty stomach Caution: [C, –] ↓ absorption w/ antacids,sucralfate, Al-, Ca-, Mg-, Fe-, Zn-containing drugs Contra: Quinolone allergyDisp: Tabs 200, 300, 400 mg; inj 20, 40 mg/mL; ophth & otic 0.3% SE: N/V/D,photosens, insomnia, HA, local irritation Notes: Ophth form OK in earsOlanzapine (Zyprexa, Zyprexa, Zydis) WARNING: Mortality inelderly w/ dementia-related psychosis Uses: *Bipolar mania, schizophrenia,*psychotic disorders, acute agitation in schizophrenia Action: Dopamine & serotoninantagonist; Dose: Bipolar/schizophrenia: 5–10 mg/d, ↑ weekly PRN, 20mg/d max; Agitation: 5-10 mg IMq2–4h PRN, 30 mg day/max Caution: [C, –]Disp: Tabs 2.5, 5, 7.5, 10, 15, 20 mg; PO disint. tabs 5, 10, 15, 20 mg; Inj 10 mgSE: HA, somnolence, orthostatic ↓ BP, tachycardia, dystonia, xerostomia, constipationNotes: Takes weeks to titrate dose; smoking ↓ levels; may be confused w/ZyrtecOlopatadine (Patanol) Uses: *Allergic conjunctivitis* Action: H 1 -receptorantagonist Dose: 1–2 gtt in eye(s) bid –allow 6-8 hours between doses Caution:[C, ?] Disp: Soln 0.1% 5 mL SE: Local irritation, HA, rhinitis Notes: wait 10minutes after drops to insert contactsOlsalazine (Dipentum) Uses: *Maint remission in UC* Action: Topicalanti-inflammatory Dose: 500 mg PO bid (w/ food) Caution: [C, M] Salicylate sensitivityDisp: Caps 250 mg SE: D, HA, blood dyscrasias, hepatitisOmalizumab (Xolair) WARNING: Reports of anaphylaxis 2–24 hoursafter administration, even in previously treated patients Uses: *Moderate–severeasthma in > / 12 y w/ reactivity to an allergen & when Sxs inadequately controlledw/ inhaled steroids* Action: Anti-IgE Ab Dose: 150–375 mg SQ q2–4wk(dose/frequency based on serum IgE level & BW, see package insert) Caution:[B,?/–] Contra: Component allergy, acute bronchospasm Disp: 150 mg single-use5-mL vial SE: Site Rxn, sinusitis, HA, anaphylaxis reported in 3 pts Notes: Continueother asthma medications as indicatedOmega-3 fatty acid [fish oil] (Louaza) Uses: *Rx hypertriglyceridemia*Action: Omega-3-acid ethyl esters, ↓ thrombus inflammation & triglyc-