Clinician's Pocket Drug Reference 2008

Amikacin 35Aluminum Hydroxide + Magnesium Hydroxide (Maalox)[OTC] Uses: *Hyperacidity* (peptic ulcer, hiatal hernia, etc) Action: Neutralizesgastric acid Dose: Adults. 10–20 mL or 2–4 tabs PO qid or PRN. Peds. 5–15mL PO qid or PRN Caution: [C, ?] Disp: Tabs, susp SE: May cause ↑ Mg 2+ inrenal insuff, constipation, D Notes: Doses qid best given pc & hsAluminum Hydroxide + Magnesium Hydroxide & Simethicone(Mylanta, Mylanta II, Maalox Plus) [OTC] Uses: *Hyperacidityw/ bloating* Action: Neutralizes gastric acid & defoaming Dose:Adults. 10–20 mL or 2–4 tabs PO qid or PRN Peds. 5–15 mL PO qid or PRN;avoid in renal impair Caution: [C, ?] Disp: Tabs, susp, liquid SE: ↑ Mg 2+ in renalinsuff, D, constipation Notes: Mylanta II contains 2X Al & Mg hydroxide of Mylanta;may affect absorption of some drugsAluminum Hydroxide + Magnesium Trisilicate (Gaviscon,Regular Strength) [OTC] Uses: *Relief of heartburn, upset or sour stomach,or acid indigestion* Action: Neutralizes gastric acid Dose: Chew 2–4 tabsqid; avoid in renal impair Caution: [C, ?] Contra: Mg 2+ , sensitivity Disp: AlOH 80mg/Mg trisilicate 20 mg/tab SE: ↑ Mg 2+ in renal insuff, constipation, D Notes:May affect absorption of some drugsAmantadine (Symmetrel) Uses: *Rx or prophylaxis influenza A,parkinsonism, & drug-induced EPS* (Note: Do not use for Influenza A in theUS—increased resistance) Action: Prevents release of infectious viral nucleic acidinto host cell; releases dopamine from intact dopaminergic terminals Dose: Adults.Influenza A: 200 mg/d PO or 100 mg PO bid. Parkinsonism: 100 mg PO daily-bid.Peds. 1–9 y.: 4.4–8.8 mg/kg/24 h to 150 mg/24 h max ÷ doses daily-bid. 10-12 y:100–200 mg/d in 1–2 ÷ doses; ↓ in renal impair Caution: [C, M] Disp: Caps 100mg; tabs 100 mg; soln 50 mg/5 mL SE: Orthostatic ↓ BP, edema, insomnia, depression,irritability, hallucinations, dream abnormalitiesAmifostine (Ethyol) Uses: *Xerostomia prophylaxis during RT (head,neck, ovarian, non-small-cell lung CA); ↓ renal tox w/ repeated cisplatin* Action:Prodrug, dephosphorylated by alkaline phosphatase to active thiol metaboliteDose: 910 mg/m 2 /d 15-min IV inf 30 min prior to chemo Caution: [C, +/–] CVdisease Disp: 500-mg vials powder, reconstitute in NS SE: Transient ↓ BP(>60%), N/V, flushing w/ hot or cold chills, dizziness, ↓ Ca 2+ , somnolence, sneezing.Notes: Does not ↓ effectiveness of cyclophosphamide + cisplatin chemoAmikacin (Amikin) Uses: *Serious gram(–) bacterial Infxns* & mycobacteriaAction: Aminoglycoside; ↓ protein synth Spectrum: Good gram(–) bacterialcoverage: Pseudomonas & Mycobacterium sp Dose: Adults & Peds. Conventional:5–7.5 mg/kg/dose q 8 h; once daily: 15–20 mg/kg q 24 h; ↑ interval w/ renal impair;Neonates 7 d, 1200–2000 g: 7 mg/kg/dose q8h; >2000 g: 7.5–10 mg/kg/dose q8h Caution:[C, +/–] avoid w/ diuretics Disp: 50 mg/mL, 250 mg/mL SE: