Clinician's Pocket Drug Reference 2008

92 Erythromycin & Benzoyl Peroxide(S. pyogenes), S. pneumoniae, N. meningitides, N. gonorrhea (if PCN-allergic), Legionella,M. pneumoniae Dose: Adults. Base 250–500 mg PO q6–12h or ethylsuccinate400–800 mg q6–12h; 500 mg–1 g IV q6h. Prokinetic: 250 mg PO tid 30 minsac. Peds. 30–50 mg/kg/d PO ÷ q6–8h or 20–40 mg/kg/d IV ÷ q6h, max 2 g/d Caution:[B, +] ↑ tox of carbamazepine, cyclosporine, digoxin, methylprednisolone,theophylline, felodipine, warfarin, simvastatin/lovastatin; ↓ sildenafil dose w/ useContra: Hepatic impair, preexisting liver Dz (estolate), use with pimozide Disp:lactobionate (Ilotycin): Powder for inj 500 mg, 1 g. Base: Tabs 250, 333, 500 mg;caps 250 mg. Estolate (Ilosone): Susp 125, 250 mg/5 mL. Stearate (Erythrocin):Tabs 250, 500 mg. Ethylsuccinate (EES, EryPed): Chew tabs 200 mg; tabs 400 mg;susp 200, 400 mg/5 mL SE: HA, abd pain, N/V/D; [QT prolongation, torsades depointes, ventricular arrhythmias/tachycardias (rarely)]; cholestatic jaundice (estolate)Notes: 400 mg ethylsuccinate = 250 mg base/estolate; w/ food minimizes GIupset; lactobionate contains benzyl alcohol (caution in neonates)Erythromycin & Benzoyl Peroxide (Benzamycin) Uses: *Topicalfor acne vulgaris* Action: Macrolide antibiotic w/ keratolytic Dose: Apply bid(AM & PM) Caution: [C, ?] Contra: Component sensitivity Disp: Gel erythromycin30 mg/benzoyl peroxide 50 mg/g SE: Local irritation, drynessErythromycin & Sulfisoxazole (Eryzole, Pediazole) Uses:*Upper & lower resp tract; bacterial Infxns; H. influenzae otitis media in children*;Infxns in PCN-allergic pts Action: Macrolide antibiotic w/ sulfonamide Dose:Adults. Based on erythromycin content; 400 mg erythromycin/1200 mg sulfisoxazolePO q6h. Peds > 2 mo. 40–50 mg/kg/d erythromycin & 150 mg/kg/d sulfisoxazolePO ÷ q6h; max 2 g/d erythromycin or 6 g/d sulfisoxazole × 10 d; ↓ in renalimpair Caution: [C (D if near term), +] w/PO anticoagulants, MRX, hypoglycemics,phenytoin, cyclosporine Contra: Infants < 2 mo Disp: Susp erythromycinethylsuccinate 200 mg/sulfisoxazole 600 mg/5 mL (100, 150, 200 mL)SE: GI upsetErythromycin, Ophthalmic (Ilotycin Ophthalmic) Uses: *Conjunctival/cornealInfxns* Action: Macrolide antibiotic Dose: 1 ⁄2 in. 2–6 X/d Caution:[B, +] Contra: Erythromycin hypersensitivity Disp: 0.5% oint SE: LocalirritationErythromycin, Topical (A/T/S, Eryderm, Erycette, T-Stat)Uses: *Acne vulgaris* Action: Macrolide antibiotic Dose: Wash & dry area, apply2% product over area bid Caution: [B, +] Contra: Component sensitivity Disp:Soln 1.5%, 2%; gel 2%; pads & swabs 2% SE: Local irritationEscitalopram (Lexapro) WARNING: Closely monitor for worsening depressionor emergence of suicidality, particularly in ped pts Uses: Depression,anxiety Action: SSRI Dose: Adults. 10–20 mg PO daily; 10 mg/d in elderly & hepaticimpair Caution: [C, +/–] Serotonin synd (Table 12) Contra: W/ or w/in 14 dof MAOI Disp: Tabs 5, 10, 20 mg; soln 1 mg/mL SE: N/V/D, sweating, insomnia,dizziness, xerostomia, sexual dysfunction Notes: Full effects may take 3 wk