Clinician's Pocket Drug Reference 2008

46 AztrenonamPeds. Otitis media: 10 mg/kg PO day 1, then 5 mg/kg/d days 2–5. Pharyngitis: 12mg/kg/d PO × 5 d (susp on empty stomach; tabs OK w/wo food; ↓ w/CrCl < 10mL/mg Caution: [B, +] Disp: Tabs 250, 500, 600 mg; Z-Pack (5-day, 250 mg);Tri-Pak (500-mg tabs × 3); susp 1-g; single-dose packet (ZMAX) ER susp. (2 gm);susp 100, 200 mg/5 mL; powder for recons 500, 2.5-mg ophtn soln 1% SE: GIupset, metallic tasteAztreonam (Azactam) Uses: *Aerobic gram(–) UTIs, lower resp, intraabd,skin, gynecologic Infxns & septicemia* Action: Monobactam. ↓ Cell wallsynth. Spectrum: Gram(–) (Pseudomonas, E. coli, Klebsiella, H. influenzae, Serratia,Proteus, Enterobacter, Citrobacter) Dose: Adults. 1–2 g IV/IM q6–12h. Peds.Premature: 30 mg/kg/dose IV q12h. Term & children: 30 mg/kg/dose q6–8h; ↓ inrenal impair Caution: [B, +] Disp: Inj (soln), 1 g, 2 gm/ 50 mL Inj powder for recons500 mg 1 g, 2 gm SE: N/V/D, rash, pain at injection site Notes: No gram(+)or anaerobic activity; OK in PCN-allergic ptsBacitracin, Ophthalmic (AK-Tracin Ophthalmic); Bacitracin& Polymyxin B, Ophthalmic (AK Poly Bac Ophthalmic,Polysporin Ophthalmic); Bacitracin, Neomycin, & PolymyxinB, Ophthalmic (AK Spore Ophthalmic, NeosporinOphthalmic); Bacitracin, Neomycin, Polymyxin B, & Hydrocortisone,Ophthalmic (AK Spore HC Ophthalmic, CortisporinOphthalmic) Uses: *Steroid-responsive inflammatory ocularconditions* Action: Topical antibiotic w/anti-inflammatory Dose: Apply q3–4hinto conjunctival sac Caution: [C, ?] Contra: Viral, mycobacterial, fungal eyeInfxn Disp: See Bacitracin, Topical equivalents, belowBacitracin, Topical (Baciguent); Bacitracin & Polymyxin B,Topical (Polysporin); Bacitracin, Neomycin, & Polymyxin B,Topical (Neosporin Ointment); Bacitracin, Neomycin, PolymyxinB, & Hydrocortisone, Topical (Cortisporin); Bacitracin,Neomycin, Polymyxin B, & Lidocaine, Topical (Clomycin)Uses: Prevent/Rx of *minor skin Infxns* Action: Topical antibiotic w/added components(anti-inflammatory & analgesic) Dose: Apply sparingly bid-qid Caution:[C, ?] Disp: Bacitracin 500 Units/g oint; Bacitracin 500 Units/polymyxin B sulfate10,000 Units/g oint & powder; Bacitracin 400 Units/neomycin 3.5 mg/polymyxin B5000 U/g oint; Bacitracin 400 Units/neomycin 3.5 mg/polymyxin B 10,000Units/hydrocortisone 10 mg/g oint; Bacitracin 500 Units/neomycin 3.5 mg/polymyxin B 5000 Units/lidocaine 40 mg/g oint Notes: Systemic & irrigation formsavailable, but not generally used due to potential toxBaclofen (Lioresal Intrathecal, generic) WARNING: IT abruptdiscontinuation can lead to organ failure, rhabdomyolysis, and death Uses:*Spasticity due to severe chronic disorders (eg, MS, ALS, or spinal cord lesions),*trigeminal neuralgia, hiccups Action: Centrally acting skeletal muscle relaxant; ↓transmission of monosynaptic & polysynaptic cord reflexes Dose: Adults. Initial, 5