Clinician's Pocket Drug Reference 2008

Ammonium Aluminum Sulfate 37tiarrhythmic (Table 10) Dose: Adults. Ventricular arrhythmias: IV: 15 mg/min for10 min, then 1 mg/min X 6 h, maint 0.5 mg/min cont inf or PO: Load: 800–1600mg/d PO X 1–3 wk. Maint: 600–800 mg/d PO for 1 mo, then 200–400 mg/d.Supraventricular arrhythmias: IV: 300 mg IV over 1 h, then 20 mg/kg for 24 h,then 600 mg PO daily for 1 wk, maint 100–400 mg daily or PO: Load 600–800mg/d PO for 1–4 wk. Maint: Slow ↓ to 100–400 mg daily(ECC 2005) Cardiac arrest:300 mg IV push; 150 mg IV push 3(-5 min PRN. Refractory pulseless VT, VF:5 mg/kg rapid IV bolus. Perfusing arrhythmias: Load: 5 mg/kg IV/IO over 20–60min (repeat, max 15 mg/kg/d) Peds. 10–15 mg/kg/24 h ÷ q12h PO for 7–10 d, then5 mg/kg/24 h ÷ q12h or daily (infants/neonates require ↑ loading); ↓ w/liver insuffCaution: [D, –] may require ↓ digoxin/warfarin dose, many drug interactionsContra: Sinus node dysfunction, 2nd-/3rd-degree AV block, sinus bradycardia(w/o pacemaker), iodine sensitivity Disp: Tabs 100, 200, 300 mg 400 mg; inj 50mg/mL SE: Pulm fibrosis, exacerbation of arrhythmias, prolongs QT interval;CHF, hypohyperthyroidism, ↑ LFTs, liver failure, corneal microdeposits, opticneuropathy/neuritis, peripheral neuropathy, photosens Notes: IV conc of >0.2mg/mL via a central catheter; Levels: Trough: just before next dose Therapeutic:1–2.5 mcg/mL; Toxic: > 2.5 mcg/mL; 1 ⁄2 life: 30–100 hAmitriptyline (Elavil) WARNING: Antidepressants may ↑ suicide risk;consider risks/benefits of use. Monitor patients closely Uses: *Depression,* peripheralneuropathy, chronic pain, tension HAs Action: TCA; ↓ reuptake of serotonin& norepinephrine by presynaptic neurons Dose: Adults. Initial, 30–50 mgPO hs; may ↑ to 300 mg hs. Peds. Not OK 500 mg/mLAmlodipine (Norvasc) Uses: *HTN, stable or unstable angina* Action:CCB; relaxes coronary vascular smooth muscle Dose: 2.5–10 mg/d PO; ↓ w/ hepaticimpair Caution: [C, ?] Disp: Tabs 2.5, 5, 10 mg SE: Peripheral edema, HA,palpitations, flushing Notes: Take w/o regard to mealsAmlodipine/Atorvastatin (Caduet) Uses: * HTN, chronic stable/vasospasticangina, control cholesterol & triglycerides* Action: CCB & HMG-CoAreductase inhibitor Dose: Amlodipine 2.5–10 mg w/ Atorvastatin 10–80 mg POdaily Caution: [X, –] Contra: Active liver Dz, ↑ LFT Disp: Tabs amlodipine/atorvastatin:2.5/10, 2.5/20, 2.5/40, 5/10, 5/20, 5/40, 5/80, 10/10, 10/20, 10/40, 10/80mg SE: Peripheral edema, HA, palpitations, flushing, myopathy, arthralgia, myalgia,GI upset Notes: LFTs; instruct patient to report muscle pain/weaknessAmmonium Aluminum Sulfate [Alum] [OTC] Uses: *Hemorrhagiccystitis when saline bladder irrigation fails* Action: Astringent Dose: 1–2%soln w/ constant NS bladder irrigation Caution: [+/–]Disp: Powder for recons SE: