Clinician's Pocket Drug Reference 2008

42 Aripiprazolew/hepatic impair Caution: [B, ?] Avoid PO anticoagulants, ↑ bleeding risk; avoiduse w/thrombolytics Contra: Overt major bleed Disp: Inj 100 mg/mL SE: AF,cardiac arrest, cerebrovascular disorder, ↓ BP, VT, N/V/D, sepsis, cough, renal tox,↓ Hgb Note: Steady state in 1–3 hAripiprazole (Abilify) WARNING: Increased mortality in elderly withdementia-related psychosis Uses: *Schizophrenia* Action: Dopamine & serotoninantagonist Dose: Adults. 10–15 mg PO daily; 5.25–15 mg for acute agitation↓ dose w/CYP3A4/CYP2D6 inhibitors (Table 11); ↑ dose w/ CYP3A4 inducerCaution: [C, –] Disp: Tabs 2, 5, 10, 15, 20, 30 mg; Discmelt (disint. tabs 10, 15,20, 30 mg, soln 1 mg/ml, inj 7.5 mg/mL SE: Neuroleptic malignant synd, tardivedyskinesia, orthostatic ↓ BP, cognitive & motor impair, ↑ glucoseArtificial Tears (Tears Naturale) [OTC] Uses: *Dry eyes* Action:Ocular lubricant Dose: 1–2 gtt tid-qid Disp: OTC solnL-Asparaginase (Elspar, Oncaspar) Uses: *ALL* (in combo w/other agents) Action: Protein synth inhibitor Dose: 500–20,000 IU/m 2 /d for 1–14d (Per protocols) Caution: [C, ?] Contra: Active/Hx pancreatitis Disp: Inj powderfor recons 10,000 units SE: Allergy 20–35% (urticaria to anaphylaxis); rare GI tox(mild N, anorexia, pancreatitis) ↑ glucose, coagulopathy Notes: test dose recommended, glucose, coagsAspirin (Bayer, Ecotrin, St. Joseph’s) [OTC] Uses: *Angina,CABG, PTCA, carotid endarterectomy, ischemic stroke, TIA, MI, arthritis, pain,*HA, *fever,* inflammation, Kawasaki Dz Action: Prostaglandin inhibitor Dose:Adults. Pain, fever: 325–650 mg q4–6h PO or PR. RA: 3–6 g/d PO in ÷ doses. Pltinhibitor: 81–325 mg PO daily. Prevent MI: 81 (preferred) –325 mg PO daily.Acute Coronary Syndrome (ECC 2005): 160–325 mg PO ASAP (chewing preferredat onset) Peds. Antipyretic: 10–15 mg/kg/dose PO or PR q4h up to 80mg/kg/24 h. RA: 60–100 mg/kg/24 h PO ÷ q4–6h (keep levels 15–30 mg/dL);avoid w/ CrCl 300 mcg/mlAspirin & Butalbital Compound (Fiorinal) [C-III] Uses: *TensionHA,* pain Action: Combo barbiturate & analgesic Dose: 1–2 PO q4h PRN, max 6tabs/d; avoid w/ CrCl