Clinician's Pocket Drug Reference 2008

Zoster vaccine, live 215Initial 2.5 mg PO, may repeat after 2 h, 10 mg max in 24 h; nasal 5 mg; if HA returns,repeat after 2 h 10 mg max 24 h Caution: [C, ?/–] Contra: Ischemic heartDz, Prinzmetal angina, uncontrolled HTN, accessory conduction pathway disorders,ergots, MAOIs Disp: Tabs 2.5, 5 mg; Rapid tabs (ZMT) 2.5, 5 mg; nasal 5mg, SE: Dizziness, hot flashes, paresthesias, chest tightness, myalgia, diaphoresisZolpidem (Ambien, Ambien CR) [C-IV] Uses: *Short-term Rx of insomnia*Action: Hypnotic agent Dose: 5–10 mg or 12.5 mg CR PO hs PRN; ↓ inelderly (use 6.25 mg CR), hepatic insuff Caution: [B, –] Contra: Breast-feedingDisp: Tabs 5, 10 mg; CR 6.25, 12.5 mg SE: HA, dizziness, drowsiness, N, myalgiaNotes: May be habit-forming; CR delivers a rapid then a longer lasting doseZonisamide (Zonegran) Uses: *Adjunct Rx complex partial Szs* Action:Anticonvulsant Dose: Initial 100 mg/d PO; may ↑ to 400 mg/d Caution:[C, –] ↑ tox w/ CYP3A4 inhibitor; ↓ levels w/ concurrent carbamazepine, phenytoin,phenobarbital, valproic acid Contra: Allergy to sulfonamides; oligohydrosis& hypothermia in peds Disp: Caps 25, 50, 100 mg SE: Dizziness, drowsiness, confusion,ataxia, memory impair, paresthesias, psychosis, nystagmus, diplopia,tremor, anemia, leukopenia; GI upset, nephrolithiasis, Stevens–Johnson synd;monitor for ↓ sweating & ↑ body temperature Notes: Swallow capsules wholeZoster vaccine, live (Zostavax) Uses: * Prevent varicella zoster inadults > 60 yrs* Action: Active immunization (live vaccine), to Herpes zosterDose: Adults. 0.65 mL SQ Contra: Gelatin, neomycin anaphylaxis; untreated TB,immunocompromise Caution: [C,?/–] not for peds Disp: SDV SE: Inj site rxn, HA