Clinician's Pocket Drug Reference 2008

Sitagliptin 187Silver Nitrate (Dey-Drop, others) Uses: *Removal of granulation tissue& warts; prophylaxis in burns* Action: Caustic antiseptic & astringent Dose:Adults & Peds. Apply to moist surface 2–3 × wk for several wks or until effectCaution: [C, ?] Contra: Do not use on broken skin Disp: Topical impregnated applicatorsticks, soln 0.5, 10, 25, 50%; ophth 1% amp; topical ointment 10% SE:May stain tissue black, usually resolves; local irritation, methemoglobinemiaNotes: D/C if redness or irritation develop; no longer used in US for newborn preventionof GC conjunctivitisSilver Sulfadiazine (Silvadene, others) Uses: *Prevention & Rx ofInfxn in 2nd- & 3rd-degree burns* Action: Bactericidal Dose: Adults & Peds.Aseptically cover the area w/ 1 ⁄16-in. coating bid Caution: [B unless near term, ?/–]Contra: Infants < 2 mo, PRG near term Disp: Cream 1% SE: Itching, rash, skindiscoloration, blood dyscrasias, hepatitis, allergy Notes: Systemic absorption w/extensive applicationSimethicone (Mylicon, others) [OTC] Uses: Flatulence Action: Defoaming,alters gas bubble surface tension action Dose: Adults & Peds. > 2 yrs.40–125 mg PO pc & hs PRN; 500 mg/D max Peds. < 2 yr: 20 mg PO QID PRN,2–12 yr 40 mg PO QID PRN, > 12 yr–adult Caution: [C, ?] Contra: GI Intestinalperforation or obst Disp: [OTC] Tabs 80, 125 mg; caps 125 mg; Softgels 125, 166,180 mg, susp 40 mg/0.6 mL, Chew tabs 80, 125 mg SE: N/D Notes: Available incombo products OTCSimvastatin (Zocor) Uses: ↓ Cholesterol Action: HMG-CoA reductaseinhibitor Dose: Adult. 5–80 mg PO; w/ meals; ↓ in renal insuff Peds. 10–17 y: 10mg, 40 mg/daily max. Caution: [X, –] Avoid concurrent use of gemfibrozil Contra:PRG, liver Dz Disp: Tabs 5, 10, 20, 40, 80 mg SE: HA, GI upset, myalgia,myopathy (muscle pain, tenderness or weakness with creatine kinase 10 × ULN),hepatitis Notes: Combo with ezetimibe/simvastatin; follow LFTsSirolimus [Rapamycin] (Rapamune) WARNING: Use only byphysicians experienced in immunosuppression; immunosuppression w/lymphoma↑ Infxns risk; do not use in lung transplant (fatal bronchial anastomotic dehiscence)Uses: *Prophylaxis of organ rejection in new tx pts.* Action: ↓ T-lymphocyte activationDose: Adults >40 kg. 6 mg PO on day 1, then 2 mg/d PO. Adults