Clinician's Pocket Drug Reference 2008

Lutropin Alfa 1351st-gen against gram (+), enhanced gram (–) Dose: Adults. 200–400 mg PO dailybid.Peds. 7.5–15 mg/kg/d PO ÷ bid; on empty stomach; ↓ in severe renal insuffCaution: [B, +] Disp: Caps 200, 400 mg; susp 100, 200 mg/5 mL SE: DLoratadine (Claritin, Alavert) Uses: *Allergic rhinitis, chronic idiopathicurticaria* Action: Nonsedating antihistamine Dose: Adults. 10 mg/d POPeds. 2–5 y: 5 mg PO daily. > 6 y: Adult dose; on empty stomach; ↓ in hepatic insuffCaution: [B, +/–] Contra: Component allergy Disp: Tabs 10 mg (OTC);rapidly disintegrating Reditabs 10 mg; syrup 1 mg/mL SE: HA, somnolence,xerostomiaLorazepam (Ativan, others) [C-IV] Uses: *Anxiety & anxiety w/ depression;preop sedation; control status epilepticus*; EtOH withdrawal; antiemeticAction: Benzodiazepine; antianxiety agent Dose: Adults. Anxiety: 1–10 mg/d POin 2–3 ÷ doses. Preop: 0.05 mg/kg to 4 mg max IM 2 h before surgery. Insomnia:2–4 mg PO hs. Status epilepticus: 4 mg/dose IV PRN q10–15 min; usual total dose8 mg. Antiemetic: 0.5–2 mg IV or PO q4–6h PRN. EtOH withdrawal: 2–5 mg IVor 1–2 mg PO initial depending on severity; titrate Peds. Status epilepticus: 0.05mg/kg/dose IV, repeat at 1–20 min intervals × 2 PRN. Antiemetic, 2–15 y: 0.05mg/kg (to 2 mg/dose) prechemo; ↓ in elderly; do not administer IV > 2 mg/min or0.05 mg/kg/min Caution: [D, ?/–] Contra: Severe pain, severe ↓ BP, sleep apnea,NAG, allergy to propylene glycol or benzyl alcohol Disp: Tabs 0.5, 1, 2 mg; soln,PO conc 2 mg/mL; inj 2, 4 mg/mL SE: Sedation, ataxia, tachycardia, constipation,resp depression Notes: ≤10 min for effect if IVLosartan (Cozaar) Uses: *HTN,* CHF, DN Action: Angiotensin II antagonistDose: 25–50 mg PO daily–bid, max 100 mg; ↓ in elderly/hepatic impairCaution: [C (1st tri, D 2nd & 3rd tri), ?/–] Disp: Tabs 25, 50, 100 mg SE: ↓ BP inpts on diuretics; GI upset, angioedemaLovastatin (Mevacor, Altocor) Uses: *Hypercholesterolemia* Action:HMG-CoA reductase inhibitor Dose: 20 mg/d PO w/ PM meal; may ↑ at 4-wk intervalsto 80 mg/d max or 60 mg ER tab; take w/ meals Caution: [X, –] Avoid w/grapefruit juice, gemfibrozil. Contra: Active liver Dz Disp: Tabs 10, 20, 40 mg;ER tabs 10, 20, 40, 60 mg SE: HA & GI intolerance common; promptly report anyunexplained muscle pain, tenderness, or weakness (myopathy) Notes: Maintaincholesterol-lowering diet; monitor LFT q12wk × 1 y, then q6moLubiprostone (Amitiza) Uses: *Chronic idiopathic constipation inadults* Action: Selective Cl channel activator Dose: Adults. 24 mcg PO bid w/food Contra: Mechanical GI obst Caution: [C,?/–] Severe D, severe renal or moderate-severehepatic impair Disp: Gelcaps 24 mcg SE: N, HA, D, GI distention,abd pain Notes: Requires (–) pregnancy test before Tx; utilize contraception; periodicallyreassess drug need; not for chronic useLutropin Alfa (Luveris) Uses: *Infertility* Action: Recombinant LHDose: 75 units SC w/ 75–150 units FSH, 2 separate inj max 14 d Caution:[X, ?/M] Contra: Primary ovarian failure, uncontrolled thyroid/adrenal dysfunc-