Clinician's Pocket Drug Reference 2008

Acyclovir 29Acetazolamide (Diamox) Uses: *Diuresis, glaucoma, prevent high-altitudesickness, refractory epilepsy* Action: Carbonic anhydrase inhibitor; ↓ renalexcretion of hydrogen & ↑ renal excretion of Na + , K + , HCO – 3 , & H 2 O Dose:Adults. Diuretic: 250–375 mg IV or PO q24h. Glaucoma: 250–1000 mg PO q24hin ÷ doses. Epilepsy: 8–30 mg/kg/d PO in ÷ doses. Altitude sickness: 250 mg POq8–12h or SR 500 mg PO q12–24h start 24–48 h before & 48 h after highest ascent.Peds. Epilepsy: 8–30 mg/kg/24 h PO in ÷ doses; max 1 g/d. Diuretic: 5mg/kg/24 h PO or IV. Alkalinization of urine: 5 mg/kg/dose PO bid-tid. Glaucoma:5–15 mg/kg/24 h PO in ÷ doses; max 1 g/d; ↓ dose w/CrCl 10–50 mL/min; avoid ifCrCl 125% IBW PO:Initial genital herpes: 200 mg PO q4h while awake, 5 caps/d × 10 d or 400 mg POtid × 7–10 d. Chronic suppression: 400 mg PO bid. Intermittent Rx: As initial Rx,