Clinician's Pocket Drug Reference 2008

Tenecteplase 197Telmisartan (Micardis) Uses: *HTN, CHF,* DN Action: Angiotensin IIreceptor antagonist Dose: 40–80 mg/d Caution: [C (1st tri; D 2nd & 3rd tri), ?/–]Contra: Angiotensin II receptor antagonist sensitivity Disp: Tabs 20, 40, 80 mgSE: Edema, GI upset, HA, angioedema, renal impair, orthostatic ↓ BPTemazepam (Restoril) [C-IV] Uses: *Insomnia,* anxiety, depression,panic attacks Action: Benzodiazepine Dose: 15–30 mg PO hs PRN; ↓ in elderlyCaution: [X, ?/–] Potentiates CNS depressive effects of opioids, barbs, EtOH, antihistamines,MAOIs, TCAs Contra: NAG Disp: Caps 7.5, 15, 22.5, 30 mg SE:Confusion, dizziness, drowsiness, hangover Notes: Abrupt D/C after > 10 d usemay cause withdrawalTemsirolimus (Torisel Kit) Uses: *Advanced RCC* Action: mTOR inhibitorDose: 25 mg IV over 30–60 min X1 week; continue until tox or progression;pre med w/25–50 mg Benadryl 30 min before Caution: [D, –]w/CYP3A4inhib/inducers (Table 11), avoid grapefruit juice, vaccines, immed postop Contra:None Disp: 25 mg/mL w/diluent SE: Hypersensitivity Rxn, rash, asthenia, mucositis,N, edema, anorexia, poor wound healing, bowel perf, ↓ Hct, WBC, plt;↑ glucose/lipids/ALP/AST/Cr Notes: Hold w/ANC < 1,000mm 3 or plt< 75,000/mm 3 ; monitor Cr, CBC; combine only w/provided diluent for IV adminTenecteplase (TNKase) Uses: *Restore perfusion & ↓ mortality w/ AMI*Action: Thrombolytic; TPA Dose: 30–50 mg; see table below Caution: [C, ?], ↑bleeding w/ NSAIDs, ticlopidine, clopidogrel, GPIIb/IIIa antagonists Contra:Bleeding, CVA, major surgery (intracranial, intraspinal) or trauma w/in 2 mo Disp:Inj 50 mg, reconstitute w/ 10 mL sterile H 2 O SE: Bleeding, allergy Notes: Do notshake w/recons; do not use w/D 5 WTenecteplase DosingWeight TNKase TNKase a Volume(kg) (mg) (mL)