Clinician's Pocket Drug Reference 2008

Droperidol 85Doxepin, Topical (Zonalon, Prudoxin) Uses: *Short-term Rx pruritus(atopic dermatitis or lichen simplex chronicus)* Action: Antipruritic; H 1 - &H 2 -receptor antagonism Dose: Apply thin coating qid,8 d max Caution: [C, ?/–]Contra: Component sensitivity Disp: 5% cream SE: ↓ BP, tachycardia, drowsiness,photosens Notes: Limit application area to avoid systemic toxDoxorubicin (Adriamycin, Rubex) Uses: *Acute leukemias;Hodgkin Dz & NHLs; soft tissue, osteo & Ewing’s sarcoma; Wilms’ tumor; neuroblastoma;bladder, breast, ovarian, gastric, thyroid, & lung CAs * Action: IntercalatesDNA; ↓ DNA topoisomerases I & II Dose: 60–75 mg/m 2 q3wk;↓ w/hepaticimpair; IV use only ↓ cardiotox w/ weekly (20 mg/m 2 /wk) or cont inf (60–90mg/m 2 over 96 h); (per protocols) Caution: [D, ?] Contra: Severe CHF, cardiomyopathy,preexisting ↓ BM, previous Rx w/total cumulative doses of doxorubicin,idarubicin, daunorubicin Disp: Inj 10, 20, 50, 75, 150, 200 mg SE: ↓ BM, venousstreaking & phlebitis, N/V/D, mucositis, radiation recall phenomenon, cardiomyopathyrare(dose-related) Notes: Limit of 550 mg/m 2 cumulative dose (400 mg/m 2w/prior mediastinal irradiation); dexrazoxane may limit cardiac tox; tissue damagew/extrav; red/orange urineDoxycycline (Adoxa, Periostat, Oracea, Vibramycin, Vibra-Tabs) Uses: *Broad-spectrum antibiotic *acne vulgaris, uncomplicated GC,chlamydia, PID, Lyme disease, skin infections, anthrax, malaria prophylaxis Action:Tetracycline; bacteriostatic; ↓ protein synth. Spectrum: Some gram (+) and (–),Rickettsia sp, Chlamydia, M. pneumoniae, B. Anthraxus Dose: Adults. 100 mg POq12h on 1st d, then 100 mg PO daily–bid or 100 mg IV q12h; acne daily dosing,chlamydia 7d, Lyme disease 14–21 d, PID 14 d Peds >8 yrs: 5 mg/kg/24 h PO, to amax of 200 mg/d ÷ daily–bid Caution: [D, +] hepatic impair Contra: Children