Clinician's Pocket Drug Reference 2008

Neomycin & Polymyxin B 151Nefazodone WARNING: Fatal hepatitis & liver failure possible, D/C ifLFT > 3× ULN, do not retreat; closely monitor for worsening depression or emergenceof suicidality, particularly in ped pts Uses: *Depression* Action: ↓ Neuronaluptake of serotonin & norepinephrine Dose: Initial 100 mg PO bid; usual300–600 mg/d in 2 ÷ doses Caution: [C, ?] Contra: w/MAOIs, pimozide, carbamazepine,alprazolam; active liver disease Disp: Tabs 50, 100, 150, 200, 250, 500mg SE: Postural ↓ BP & allergic Rxns; HA, drowsiness, xerostomia, constipation,GI upset, liver failure Notes: Monitor LFTs, HR, BPNelarabine (Arranon) WARNING: Fatal neurotoxicity possible Uses:*T-cell ALL or T-cell LBL unresponsive > 2 other regimens* Action: Nucleosideanalog Dose: Adults. 1500 mg/m 2 IV over 2 hr days 1, 3, 5 of 21-day cycle Peds.650 mg/m 2 IV over 1 hr on days 1–5 of 21-day cycle Caution: [D,?/–] Disp: Vial250 mg SE: Neuropathy, ataxia, seizures, coma, hematologic toxicity, GI upset,HA, blurred vision Notes: Prehydration, urinary alkalinization, allopurinol beforedose; monitor CBCNelfinavir (Viracept) Uses: *HIV Infxn* Action: Protease inhibitor causesimmature, noninfectious virion production Dose: Adults. 750 mg PO tid or 1250 mgPO bid. Peds. 25–35 mg/kg PO tid; take w/ food Caution: [B, ?] Many drug interactionsContra: Phenylketonuria, triazolam/midazolam use or drug dependent onCYP3A4 (Table 11) Disp: Tabs 250, 625 mg; powder 50 mg/g; SE: Food ↑ absorption;interacts w/ St. John’s wort; dyslipidemia, lipodystrophy, D, rashNeomycin, Bacitracin, & Polymyxin B (Neosporin Ointment)(See Bacitracin, Neomycin, & Polymyxin B Topical,page 46)Neomycin, Colistin, & Hydrocortisone (Cortisporin-TC OticDrops); Neomycin, Colistin, Hydrocortisone, & Thonzonium(Cortisporin-TC Otic Susp) Uses: *External otitis,* Infxns ofmastoid/fenestration cavities Action: Antibiotic w/anti-inflammatory Dose:Adults. 4–5 gtt in ear(s) tid–qid. Peds. 3–4 gtt in ear(s) tid–qid Contra: componentallergy; HSV, vaccinia, varicella Caution: [C, ?] Disp: Otic gtt & susp SE: LocalirritationNeomycin & Dexamethasone (AK-Neo-Dex Ophthalmic,NeoDecadron Ophthalmic) Uses: *Steroid-responsive inflammatoryconditions of the cornea, conjunctiva, lid, & anterior segment* Action: Antibioticw/ anti-inflammatory corticosteroid Dose: 1–2 gtt in eye(s) q3–4h or thin coattid–qid until response, then ↓ to daily Caution: [C, ?] Disp: Cream neomycin0.5%/dexamethasone 0.1%; oint neomycin 0.35%/dexamethasone 0.05%; solnneomycin 0.35%/dexamethasone 0.1% SE: Local irritation Notes: Use under ophthalmologist’ssupervisionNeomycin & Polymyxin B (Neosporin Cream) [OTC] Uses:*Infxn in minor cuts, scrapes, & burns* Action: Bactericidal Dose: Apply bid–qidCaution: [C, ?] Contra: Component allergy Disp: Cream neomycin 3.5