Clinician's Pocket Drug Reference 2008

Labetalol 127matophytes & yeast; shampoo for dandruff,* PCa when rapid ↓ testosteroneneeded (ie, cord compression) Action: ↓ fungal cell wall synth Dose: Adults. PO:200 mg PO daily; ↑ to 400 mg PO daily for serious Infxn; PCa 400 mg PO tid(short-term). Topical: Apply daily (cream/shampoo). Peds >2 y. 5–10 mg/kg/24 hPO ÷ q12–24h (↓ in hepatic Dz) Caution: [C, +/–] Any agent that ↑ gastric pHprevents absorption; may enhance anticoagulants; w/ EtOH (disulfiram-like Rxn)numerous interactions Contra: CNS fungal Infxns (poor CNS penetration),w/astemizole, triazolam; topical use on broken/inflamed skin Disp: Tabs 200 mg;topical cream 2%; gel 2%, shampoo 1% and 2% SE: N Notes: Monitor LFTs w/systemic useKetoprofen (Orudis, Oruvail) WARNING: May ↑risk of cardiovascularevents & GI bleeding Uses: *Arthritis, pain* Action: NSAID;↓ prostaglandins Dose: 25–75 mg PO tid–qid, 300 mg/d/max; w/ food Caution:[B (D 3rd tri), ?] Contra: NSAID/ASA sensitivity Disp: Caps 25, 50, 75 mg; caps,SR 100, 150, 200 mg SE: GI upset, peptic ulcers, dizziness, edema, rashKetorolac (Toradol) WARNING: Indicated for short-term (= 5 d) Rx ofmoderate–severe acute pain that requires opioid analgesia levels Uses: *Pain*Action: NSAID; ↓ prostaglandins Dose: 15–30 mg IV/IM q6h or 10 mg PO qid;max IV/IM 120 mg/d, max PO 40 mg/d; do not use for >5 d; ↓ for age & renal dysfunctionand < 50 kg Caution: [B (D 3rd tri), –] Contra: Peptic ulcer Dz, NSAIDsensitivity, advanced renal Dz, CNS bleeding, anticipated major surgery, labor &delivery, nursing mothers Disp: Tabs 10 mg; inj 15 mg/mL, 30 mg/mL SE: Bleeding,peptic ulcer Dz, renal failure, Cr, edema, dizziness, allergy Notes: PO only ascontinuation of IM/IV therapyKetorolac Ophthalmic (Acular, Acular LS, Acular PF) Uses:*Ocular itching w/ seasonal allergies*; inflammation w/ cataract extraction;pain/photophobia w/ incisional refractive surgery (Acular PF); Pain w/ corneal refractivesurgery (Acular LS) Action: NSAID Dose: 1 gtt qid Caution: [C, +]Disp: Acular LS: 0.4%; Acular, Acular PF Soln 0.5% SE: Local irritationKetotifen (Zaditor) Uses: *Allergic conjunctivitis* Action: H 1 -receptorantagonist, mast cell stabilizer Dose: Adults & Peds. 1 gtt in eye(s) q8–12h Caution:[C,?/–] Disp: Soln 0.025%/5 mL SE: Local irritation, HA, rhinitisKunecatechins (Veregen) Uses: *External genital/perianal warts* Action:Unknown Dose: Apply 0.5 cm ribbon to each wart 3 ×/day until all wartsclear; not > 16 wks) Caution: [C; ?] Disp: Oint 15% SE: Local rxns (erythema,pruritus, burning, pain, erosion/ulceration, edema, induration, rash) Notes: Washhands before/after use; not necessary to wipe off prior to next useLabetalol (Trandate) Uses: *HTN* & hypertensive emergencies (IV) Action:α & β-adrenergic blocker Dose: Adults. HTN: Initial, 100 mg PO bid, then200–400 mg PO bid. Hypertensive emergency: 20–80 mg IV bolus, then 2 mg/minIV inf, titrate up to 300 mg; 10 mg IV over 1–2 min; repeat or double dose q 10min (150 mg max); or initial bolus, then 2–8 mg/min (ECC 2005) Peds. PO: 3–20