Clinician's Pocket Drug Reference 2008

162 Oxycodone & AspirinPO q4–6h PRN (acetaminophen max dose 4 g/d). Peds. Oxycodone 0.05–0.15mg/kg/dose q 4–6h PRN, 5 mg/dose max Caution: [C (D prolonged use or nearterm), M] Contra: Allergy, resp depression Disp: Percocet tabs, mg oxycodone/mgAPAP: 2.5/325, 5/325, 7.5/325, 10/325, 7.5/500, 10/650; Tylox caps 5mg oxycodone, 500 mg APAP; soln 5 mg oxycodone & 325 mg APAP/5 mL SE: ↓BP, sedation, dizziness, GI upset, constipationOxycodone & Aspirin (Percodan, Percodan-Demi) [C-II]Uses: *Moderate–moderately severe pain* Action: Narcotic analgesic w/ NSAIDDose: Adults. 1–2 tabs/caps PO q4–6h PRN. Peds. Oxycodone 0.05–0.15mg/kg/dose q 4–6h PRN, up to 5 mg/dose; ↓ in severe hepatic failure Caution: [Dprolonged use or near term), M] Peptic ulcer Contra: Component allergy, children(< 16 y) with viral infection, resp depression, ileus Disp: Percodan 4.5 mg oxycodonehydrochloride, 0.38 mg oxycodone terephthalate, 325 mg ASA; Percodan-Demi 2.25 mg oxycodone hydrochloride, 0.19 mg oxycodone terephthalate, 325mg ASA SE: Sedation, dizziness, GI upset, constipationOxycodone/Ibuprofen (Combunox) [C-II] WARNING: May ↑risk of serious CV events; contra in peri-op CABG pain; ↑ risk of GI events suchas bleeding Uses: *Short-term (not >7 d) management of acute moderate–severepain* Action: Narcotic w/NSAID Dose: 1 tab q6h prn 4 tab max/24 h; 7 days max.Caution: [C, –] w/ impaired renal/hepatic Fxn; COPD, CNS depression Contra:Paralytic ileus, 3rd tri PRG, allergy to ASA or NSAIDs, where opioids are contraindicatedDisp: Tabs 5 mg oxycodone/400 mg ibuprofen SE: N/V, somnolence,dizziness, sweating, flatulence, ↑ LFTs Notes: Monitor renal Fxn; abuse potentialw/ oxycodoneOxymorphone (Opana,Opana ER) [C-II] WARNING: (Opana ER)Abuse potential, controlled release only for chronic pain; do not consume EtOHcontaing beverages, may cause fatal OD Uses: *Moderate/severe pain, sedative*Action: Narcotic analgesic Dose: 10–20 mg PO q4–6h prn if opioid-naïve or 1–1.5mg SC/IM q4–6 prn or 0.5 mg IV q4–6h prn; start 20 mg/dose max PO; Chronicpain: Extended release 5 mg PO q12h; if opioid-naïve ↑ PRN 5–10 mg PO q12hq3–7 d; take 1h PC or 2h AC; ↓ dose w/ elderly, renal/hepatic impair Caution: [B, ?]Contra: ↑ ICP, severe resp depression, w/ETOH or liposomal morphine, severe hepaticimpair Disp: Tab 5, 10 mg; ER 5, 10, 20, 40 SE: ↓ BP, sedation, GI upset,constipation, histamine release Notes: Related to hydromorphoneOxytocin (Pitocin) Uses: *Induce labor, control postpartum hemorrhage*;promote milk letdown in lactating women Action: Stimulate muscular contractionsof the uterus & milk flow during nursing Dose: 0.0005–0.001 units/min IV inf;titrate 0.001–0.002 units/ min q 30-60 mins. Breast-feeding: 1 spray in both nostrils2–3 min before feeding Caution: [Uncategorized, no anomalies expected, +/–]Contra: Where vaginal delivery not favorable, fetal distress Disp: Inj 10 units/mL;nasal soln 40 units/mL SE: Uterine rupture, fetal death; arrhythmias, anaphylaxis,H 2 O intox Notes: Monitor vital signs; nasal form for breast-feeding only