Clinician's Pocket Drug Reference 2008

96 Estrogen, Conjugated Syntheticestrogen-dependent tumors, thromboembolic disorders, thrombosis, thrombophlebitis,recent MI Disp: Tabs 0.3, 0.625, 0.9, 1.25, 2.5 mg; inj 25 mg/mL, vagcream 0.625 mg/gm SE: ↑ Risk of endometrial CA, gallbladder Dz, thromboembolism,HA, & possibly breast CA; generic products not equivalentEstrogen, Conjugated Synthetic (Cenestin, Enjuvia) WARN-ING: Do not use in the prevention of CV Dz or dementia; ↑ risk of endometrialcancer Uses: *Vasomotor menopausal Sxs, vulvovaginal atrophy, prevent postmenopausalosteoporosis* Action: Multiple estrogen hormonal replacement Dose:for all w/intact uterus progestin × 10–14 days/28-day cycle; Vasomotor 0.3–1.25 mg(Enjuvia) 0.625–1.25 mg (Cenestin) PO daily; Vaginal atrophy 0.3 mg/day; osteoporosis(Cenestin) 0.625 mg/day Caution: [X, –] Contra: See estrogen, conjugatedDisp: Tabs Cenestin 0.3, 0.45, 0.625, 0.9 mg; Enjuvia ER 0.3, 0.45, 0.625, 1.25 mgSE: ↑ risk endometrial/breast CA, gallbladder Dz, thromboembolismEstrogen, Conjugated + Medroxyprogesterone (Prempro,Premphase) WARNING: Should not be used for the prevention of CV Dzor dementia; ↑ risk of dementia in premenopausal women; the WHI study reported↑ risk of MI, stroke, breast CA, PE, & DVT over 5 y of Rx Uses: *Moderate–severe menopausal vasomotor Sxs; atrophic vaginitis; prevent postmenopausal osteoporosis*Action: Hormonal replacement Dose: Prempro 1 tab PO daily; Premphase1 tab PO daily Caution: [X, –] Contra: Severe hepatic impair, genitalbleeding of unknown cause, breast CA, estrogen-dependent tumors, thromboembolicdisorders, thrombosis, thrombophlebitis Disp: (as estrogen/medroxyprogesterone)Prempro: Tabs 0.625/2.5, 0.625/5 mg; Premphase: Tabs 0.625/0 (days1–14) & 0.625/5 mg (days 15–28) SE: Gallbladder Dz, thromboembolism, HA,breast tenderness Notes: See Women’s Health Initiative www.whi.orgEstrogen, Conjugated + Methylprogesterone (Premarin +Methylprogesterone) WARNING: Do not use in the prevention of CVDz or dementia; ↑ risk of endometrial cancer Uses: *Menopausal vasomotor Sxs;osteoporosis* Action: Estrogen & androgen combo Dose: 1 tab/d Caution: [X, –]Contra: Severe hepatic impair, AUB, breast CA, estrogen-dependent tumors,thromboembolic disorders, thrombosis, thrombophlebitis Disp: Tabs 0.625 mg estrogen,conjugated, & 2.5 or 5 mg of methylprogesterone SE: N, bloating, breastenlargement/tenderness, edema, HA, hypertriglyceridemia, gallbladder DzEstrogen, Conjugated + Methyltestosterone (Premarin +Methyltestosterone) WARNING: Do not use in the prevention of CV Dzor dementia; ↑ risk of endometrial cancer Uses: *Moderate–severe menopausalvasomotor Sxs*; postpartum breast engorgement Action: Estrogen & androgencombo Dose: 1 tab/d × 3 wk, then 1 wk off Caution: [X, –] Contra: Severe hepaticimpair, genital bleeding of unknown cause, breast CA, estrogen-dependenttumors, thromboembolic disorders, thrombophlebitis Disp: Tabs (estrogen/methyltestosterone) 0.625 mg/5 mg, 1.25 mg/10 mg SE: N, bloating, breast enlargement/tenderness,edema, HA, hypertriglyceridemia, gallbladder Dz