Clinician's Pocket Drug Reference 2008

Trifluridine Ophthalmic 207& oint 15, 30, 60, 120 mg SE: Local irritation, hypertrichosis, pigmentationchanges Notes: For short-term use (< 7 d)Triamterene (Dyrenium) Uses: *Edema associated w/ CHF, cirrhosis*Action:K + -sparing diuretic Dose: Adults. 100–300 mg/24 h PO ÷ daily–bid. Peds.HTN 2–4 mg/kg/d in 1–2 ÷ doses; ↓ w/renal/hepatic impair Caution: [B (manufacturer;D ed. opinion), ?/–] Contra: ↑ K + , renal impair; caution w/other K + -sparing diureticsDisp: Caps 50, 100 mg SE: ↓ K + , blood dyscrasias, liver damage, other RxnsTriazolam (Halcion) [C-IV] Uses: *Short-term management ofinsomnia* Action: Benzodiazepine Dose: 0.125–0.25 mg/d PO hs PRN; ↓ in elderlyCaution: [X, ?/–] Contra: NAG; cirrhosis; concurrent amprenavir, ritonavir,nelfinavir, itraconazole, ketoconazole, nefazodone Disp: Tabs 0.125, 0.25 mg SE:Tachycardia, CP, drowsiness, fatigue, memory impair, GI upset Notes: AdditiveCNS depression w/ EtOH & other CNS depressants, avoid abrupt D/C, do not prescribe> 1 mo supplyTriethanolamine (Cerumenex) [OTC] Uses: *Cerumen (ear wax) removal*Action: Ceruminolytic agent Dose: Fill ear canal & insert cotton plug; irrigatew/ H 2 O after 15 min; repeat PRN Caution: [C, ?] Contra: Perforatedtympanic membrane, otitis media Disp: Soln 10, 16, 12 mL SE: Local dermatitis,pain, erythema, pruritusTriethylenetriphosphamide (Thio-Tepa, Tespa, TSPA) Uses:*Hodgkin Dz & NHLs; leukemia; breast, ovarian CAs, preparative regimens for allogeneic& ABMT w/ high doses, intravesical for bladder CA* Action: Polyfunctionalalkylating agent Dose: 0.5 mg/kg q1–4wk, 6 mg/m 2 IM or IV × 4 d q2–4wk,15–35 mg/m 2 by cont IV inf over 48 h; 60 mg into the bladder & retained 2 hq1–4wk; 900–125 mg/m 2 in ABMT regimens (highest dose w/o ABMT is 180mg/m 2 ); 1–10 mg/m 2 (typically 15 mg) IT 1 or 2 X/wk; 0.8 mg/kg in 1–2 L of solnmay be instilled intraperitoneally; ↓ in renal failure Caution: [D, –] Contra: Componentallergy Disp: Inj 15, 30 mg SE: ↓ BM, N/V, dizziness, HA, allergy, paresthesias,alopecia Notes: Intravesical use in bladder Ca infrequent todayTrifluoperazine (Stelazine) Uses: *Psychotic disorders* Action: Phenothiazine;blocks postsynaptic CNS dopaminergic receptors Dose: Adults. 2–10mg PO bid. Peds 6–12 y. 1 mg PO daily–bid initial, gradually ↑ to 15 mg/d; ↓ inelderly/debilitated pts Caution: [C, ?/–] Contra: Hx blood dyscrasias; phenothiazinesensitivity Disp: Tabs 1, 2, 5, 10 mg; PO conc 10 mg/mL; inj 2 mg/mL SE:Orthostatic ↓ BP, EPS, dizziness, neuroleptic malignant synd, skin discoloration,lowered Sz threshold, photosens, blood dyscrasias Notes: PO conc must be dilutedto 60 mL or more prior to administration; requires several weeks for onset of effectsTrifluridine Ophthalmic (Viroptic) Uses: *Herpes simplex keratitis &conjunctivitis* Action: Antiviral Dose: 1 gt q2h (max 9 gtt/d); ↓ to 1 gtt q4h afterhealing begins; Rx up to 21 d Caution: [C, M] Contra: Component allergy Disp:Soln 1% SE: Local burning, stinging