Clinician's Pocket Drug Reference 2008

Levonorgestrel IUD 131Disp: Multidose inhaler (HFA) 45 mcg/puff (15 gm); Soln neb inhal 0.31, 0.63,1.25 mg/3 mL SE: paradox bronchospasm, anaphylaxis, angioedema, tachycardia,nervousness,V Notes: May ↓ CV side effects compared w/ albuterol; do not mixw/other nebs or diluteLevetiracetam (Keppra) Uses: *Partial onset Szs* Action: UnknownDose: Adults and >16 y. 500 mg PO bid, may ↑ 3000 mg/d max; Peds. 4–15 y:10–20 mg/kg/d ÷ in 2 doses, 60 mg/kg/d max (↓ in renal insuff) Caution:[C, ?/–]elderly, w/renal impair, psych disorders Contra: Component allergy Disp:Tabs 250, 500, 750, 1000 mg, Sol 100 mg/mL SE: Dizziness, somnolence, HA,hostility, aggression, myelosupp, impaired coordination Notes: Do not D/CabruptlyLevobunolol (A-K Beta, Betagan) Uses: *Glaucoma* Action:β-Adrenergic blocker Dose: 1 gtt daily–bid Caution: [C, ?] Disp: Soln 0.25, 0.5%SE: Ocular stinging or burning Notes: Possible systemic effects if absorbedLevocabastine (Livostin) Uses: *Allergic seasonal conjunctivitis* Action:Antihistamine Dose: 1 gtt in eye(s) qid ≤ 2 wk Caution: [C,+/–] Disp: 0.05% gttSE: Ocular discomfortLevofloxacin (Levaquin, Quixin & Iquix Ophthalmic) Uses:*Lower resp tract Infxns, sinusitis, chronic bact prostatitis, pyelonephritis, UTI uncomp;skin Infxns; anthrax; topical for bacterial conjunctivitis* Action:Quinolone, ↓ DNA gyrase. Spectrum: Excellent gram (+) except MRSA & E. faecium;excellent gram (–) except S. maltophilia & Acinetobacter sp; poor anaerobicDose: Usual 250–750 mg/d PO or IV; Sinusitis 750 mg PO/IV day × 5; Prostatitis500 mg PO/IV daily × 28 D; Uncomp UTI female 250 mg PO/IV daily × 3, if complicated× 10 days; CAP 750 mg/day for 5 d; Anthrax acute 500 mg PO/d X 60,start IV w/other antib; postexposure 500 mg PO daily × 60; ophth 1–2 gtt in eye(s)q2h while awake for 2 d, then q4h while awake for 5 d; ↓ in renal impair, avoidantacids if PO; oral sol 1 h before, 2 h after meals Caution: [C, –] w/ cation-containingproducts (eg, antacids) Contra: Quinolone sensitivity Disp: Tabs 250, 500,750 mg; premixed IV 250, 500, 750 mg, inj 25 mg/mL; Leva-Pak 750 mg × 5 d;Sol: 25 mg/mL ophth soln 0.5% (Quixin), 1.5% (Iquix) SE: N/D, dizziness, rash,GI upset, photosensLevonorgestrel (Plan B) Uses: *Emergency contraceptive (“morningafterpill”)*; prevents PRG if taken 18 y, RX if < 18 y varies by stateLevonorgestrel IUD (Mirena) Uses: *Contraception, long term* Action:?, may alter endometrium, thicken cervical mucus, interfere w/sperm survivalor capacitation Dose: Up to 5 yrs, insert w/in 7 days menses onset or immed after