Clinician's Pocket Drug Reference 2008

Oxycodone & Acetaminophen 161membranes Dose: Adults. 300 mg PO bid, ↑ weekly to target maint 1200–2400mg/d. Peds. 8–10 mg/kg bid, 600 mg/d max, ↑ weekly to target maint dose; ↓ w/renal insuff Caution: [C, –] carbamazepine sensitivity; Contra: Components sensitivityDisp: Tabs 150, 300, 600 mg; Susp 300 mg/5 mL SE: ↓ Na + , HA, dizziness,fatigue, somnolence, GI upset, diplopia, concentration difficulties, fatalskin/multiorgan hypersensitivity Rxns Notes: Do not abruptly D/C, Na + if fatigued;advise about Stevens–Johnson synd and topic epidermal necrolysisOxiconazole (Oxistat) Uses: *Tinea cruris, corporis, pedis, versicolor *Action: ? ↓ ergosterols in fungal cell membrane Spectrum: Most Epidermophytonfloccosum, Trichophyton mentagrophytes, Trichophyton rubrum, Malassezia furfurDose: Apply thin layer daily- bid Caution: [B, M] Contra: Component allergyDisp: Cream, lotion 1% SE: Local irritationOxybutynin (Ditropan, Ditropan XL) Uses: *Symptomatic relief ofurgency, nocturia, incontinence w/ neurogenic or reflex neurogenic bladder* Action:Anicholinergic, relaxes bladder smooth muscle, ↑ bladder capacity Dose:Adults & Peds > 5 y. 5 mg PO tid–qid; XL 5 mg PO daily; ↑ to 30 mg/d PO (5 &10 mg/tab). Peds 1–5 y. 0.2 mg/kg/dose bid–qid (syrup 5 mg/5 mL); ↓ in elderly;periodic drug holidays OK Caution: [B, ?] Contra: NAG, MyG, GI/GU obstr, ulcerativecolitis, megacolon Disp: Tabs 5 mg; XL tabs 5, 10, 15 mg; syrup 5 mg/5mLSE: Anticholinergic (drowsiness, xerostomia, constipation, tachycardia), ERform shell expelled in stoolOxybutynin Transdermal System (Oxytrol) Uses: *Rx OAB* Action:Anicholinergic, relaxes bladder smooth muscle, ↑ bladder capacity ↑ Dose:One 3.9 mg/d system apply 2×/wk (every 3–4 days) to abdomen, hip, or buttockCaution: [B, ?/–] Contra: GI/GU obstr, NAG Disp: 3.9 mg/d transdermal patch SE:Anticholinergic, itching/redness at site Notes: Do not apply to same site w/in 7 dOxycodone [Dihydrohydroxycodeinone] (OxyContin, OxyIR,Roxicodone) [C-II] WARNING: High abuse potential; controlled releaseonly for extended chronic pain, not for PRN use; 80 mg ER tabs only for opoid tolerantpatients Uses: *Moderate/severe pain, usually in combo w/ nonnarcoticanalgesics* Action: Narcotic analgesic Dose: Adults. 5 mg PO q6h PRN (immedrelease); Mod-severe chronic pain 10–160 mg PO q12h (extended release) Peds.6–12 y: 1.25 mg PO q6h PRN. > 12 y: 2.5 mg q6h PRN; ↓ w/ severe liver/renalDz, elderly; w/ food Caution: [B (D if prolonged use/near term), M] Contra: Allergy,resp depression, acute asthma, ileus w/microsomal morphine Disp: Immedreleasecaps (OxyIR) 5 mg; tabs (Percolone) 5 mg; CR Roxicodone tabs 5, 15, 30mg; Extended relase (OxyContin) 10, 20, 40, 80 mg; liq 5 mg/5 mL; soln conc 20mg/mL SE: ↓ BP, sedation, dizziness, GI upset, constipation, risk of abuse Notes:OxyContin for chronic CA pain; do not crush/chew/cut ER prod; sought after asdrug of abuseOxycodone & Acetaminophen (Percocet, Tylox) [C-II] Uses:*Moderate–severe pain* Action: Narcotic analgesic Dose: Adults. 1–2 tabs/caps