Clinician's Pocket Drug Reference 2008

Tetracycline 199Terconazole (Terazol 7) Uses: *Vaginal fungal Infxns* Action: Topicaltriazole antifungal Dose: 1 applicatorful or 1 supp intravag hs × 3–7 d Caution:[C, ?] Contra: Component allergy Disp: Vaginal cream 0.4, 0.8%, vaginal supp 80mg SE: Vulvar/vaginal burning Notes: Insert high into vaginaTeriparatide (Forteo) WARNING: ↑ osteosarcoma risk in animals, thereforeonly use in pts for whom the potential benefits outweigh risks Uses: *Severe/refractoryosteoporosis* Action: PTH (recombinant) Dose: 20 mcg SQ dailyin thigh or abdomen Caution: [C, ?/–] Contra: w/ Paget Dz, prior radiation, bonemetastases, ↑ Ca 2+ ; caution in urolithiasis Disp: 3-mL prefilled device (discardafter 28 d) SE: orthostatic ↓ BP on administration, N/D, ↑ Ca, leg cramps Notes: 2yr max use; osteosarcoma in animalsTestosterone (AndroGel, Androderm, Striant, Testim) [CIII]Uses: *Male hypogonadism * Action: Testosterone replacement; ↑ lean bodymass, libido Dose: All daily AndroGel: 5 g gel. Androderm: two 2.5-mg or one 5-mg patch daily. Striant: 30-mg buccal tabs bid. Testim: one 5-g gel tube. Caution:[N/A, N/A] Contra: PCa, male breast CA Disp: AndroGel, Testim: 5-gm gel (50-mg test); Androderm: 2.5-, 5-mg patches; Striant: 30-mg buccal tabs SE: SiteRxns, acne, edema, wgt gain, gynecomastia, HTN, ↑ sleep apnea, prostate enlargementNotes: Injectable testosterone enanthate (Delatestryl; Testro-L.A.) & cypionate(Depo-Testosterone) require inj every 14–28 d with highly variable serumlevels; PO agents (methyltestosterone & oxandrolone) associated w/ hepatitis/hepatictumors; transdermal/mucosal forms preferredTetanus Immune Globulin Uses: *Passive tetanus immunization * (suspectedcontaminated wound w/ unknown immunization status, see also Table 8)Action: Passive immunization Dose: Adults & Peds. 250–500 units IM (higherdose w/ delayed Rx) Caution: [C, ?] Contra: Thimerosal sensitivity Disp: Inj250-unit vial/syringe SE: Pain, tenderness, erythema at site; fever, angioedema,muscle stiffness, anaphylaxis Notes: May begin active immunization series at differentinj site if requiredTetanus Toxoid Uses: *Tetanus prophylaxis* Action: Active immunizationDose: Based on previous immunization, Table 8 Caution: [C, ?] Contra: Chloramphenicoluse, neurologic Sxs w/ previous use, active Infxn w/ routine primaryimmunization Disp: Inj tetanus toxoid, fluid, 4–5 Lf units/0.5 mL; tetanus toxoid,adsorbed, 5, 10 Lf units/0.5 mL SE: Local erythema, induration, sterile abscess,chills, fever, neurologic disturbancesTetracycline (Achromycin V, Sumycin) Uses: *Broad-spectrum antibiotic*Action: Bacteriostatic; ↓ protein synth. Spectrum: Gram (+):Staph, Strep;Gram(–): H. pylori; Atypicals: Chlamydia, Rickettsia, & Mycoplasma Dose:Adults. 250–500 mg PO bid–qid. Peds > 8 y. 25–50 mg/kg/24 h PO q6–12h; ↓w/ renal/hepatic impair, w/o food preferred Caution: [D, +] Contra: PRG,antacids, w/ dairy products, children ≤8 y Disp: Caps 100, 250, 500 mg; tabs 250,500 mg; PO susp 250 mg/5 mL SE: Photosens, GI upset, renal failure, pseudotu-