Clinician's Pocket Drug Reference 2008

Chlorothiazide 61dairy Contra: Not effective for cyanide, mineral acids, caustic alkalis, organic solvents,iron, EtOH, methanol poisoning, Li; do not use sorbitol in pts w/fructose intolerance,intestional obst, nonintact GI tracts Disp: Powder, liq, caps SE: Someliq dosage forms in sorbitol base (a cathartic); V/D, black stools, constipationNotes: Charcoal w/ sorbitol not OK in children 6 y. 0.5mg/kg/24 h PO or IM ÷ q6–8h; ↓ in renal impair, elderly Caution: [D, ?] Resp depression,CNS impair, Hx of drug dependence; avoid in hepatic impair Contra:Preexisting CNS depression, NAG Disp: Caps 5, 10, 25 mg; inj 100 mg SE:Drowsiness, CP, rash, fatigue, memory impair, xerostomia, wgt gain Notes: ErraticIM absorptionChlorothiazide (Diuril) Uses: *HTN, edema* Action: Thiazide diureticDose: Adults. 500 mg–1 g PO daily-bid; 100–1000 mg/d IV (for edema only).Peds >6 mo. 20–30 mg/kg/24 h PO ÷ bid; 4 mg/kg/d IV; OK w/food Caution:[D, +] Contra: Cross-sensitivity to thiazides/sulfonamides, anuria Disp: Tabs 250,500 mg; susp 250 mg/5 mL; inj 500 mg/vial SE: ↓ K + , Na + , dizziness, hyperglycemia,hyperuricemia, hyperlipidemia, photosens Notes: Do not use IM/SQ;take early in the day to avoid nocturia; use sunblock; monitor lytes