Clinician's Pocket Drug Reference 2008

Celecoxib 59IV/im q8–12h. Peds. 30–50 mg/kg/dose IV q8h; ↓ in renal impair Caution: [B, +]PCN sensitivity Contra: Cephalosporin allergy Disp: Powder for inj 500 mg, 1, 2,6 g SE: D, rash, eosinophilia, ↑ transaminases. Notes: Use only for proven orstrongly suspected Infxn to ↓ development of drug resistanceCeftibuten (Cedax) Uses: *Rx resp tract, skin, urinary tract Infxns & otitismedia* Action: 3rd-gen cephalosporin; ↓ cell wall synth. Spectrum: H. influenzae& M. catarrhalis; weak against S. pneumoniae Dose: Adults. 400 mg/d PO. Peds.9 mg/kg/d PO; ↓ in renal impair; take on empty stomach (susp) Caution: [B, +]Contra: Cephalosporin allergy Disp: Caps 400 mg; susp 90 mg/5 mL SE: D, rash,eosinophilia, ↑ transaminasesCeftizoxime (Cefizox) Uses: *Rx resp tract, skin, bone, & urinary tractInfxns, meningitis, septicemia* Action: 3rd-gen cephalosporin; ↓ cell wall synth.Spectrum: Good gram(–) bacilli (not Pseudomonas), some gram(+) cocci (not Enterococcus),& some anaerobes Dose: Adults. 1–4g IV q8–12h. Peds. 150–200mg/kg/d IV ÷ q6–8h; ↓ in renal impair Caution: [B, +] Contra: Cephalosporin allergyDisp: Inj 1, 2, 10 g SE: D, fever, rash, eosinophilia, thrombocytosis, ↑transaminasesCeftriaxone (Rocephin) Uses: *Resp tract (pneumonia), skin, bone, urinarytract Infxns, meningitis, & septicemia;* Action: 3rd-gen cephalosporin; ↓cell wall synth. Spectrum: Moderate gram(+); excellent against β-lactamase producersDose: Adults. 1–2 g IV/IM q12-24h. Peds. 50–100 mg/kg/d IV/IM ÷q12–24h; ↓ in renal impair Caution: [B, +] Contra: Cephalosporin allergy; hyperbilirubinemicneonates Disp: Powder for inj 250 mg, 500 mg, 1, 2, 10 g; premixed10, 20, 40 mg/mL SE: D, rash, leukopenia, thrombocytosis, eosinophilia, ↑transaminasesCefuroxime (Ceftin [PO], Zinacef [parenteral]) Uses: *Upper &lower resp tract, skin, bone, urinary tract, abdomen, gynecologic Infxns* Action:2nd-gen cephalosporin; ↓ cell wall synth Spectrum: Staphylococci, group B streptococci,H. influenzae, E. coli, Enterobacter, Salmonella, & Klebsiella Dose:Adults. 750 mg–1.5 g IV q6h or 250–500 mg PO bid. Peds. 100–150 mg/kg/d IV ÷q8h or 20–30 mg/kg/d PO ÷ bid; ↓ in renal impair; take w/ food Caution: [B, +]Contra: Cephalosporin allergy Disp: Tabs 125, 250, 500 mg; susp 125, 250 mg/5mL; powder for inj 750 mg, 1.5, 7.5 g SE: D, rash, eosinophilia, ↑ LFTs Notes:Cefuroxime film-coated tabs & susp not bioequivalent; do not substitute on amg/mg basis; IV crosses blood-brain barrierCelecoxib (Celebrex) WARNING: ↑ Risk of serious CV thromboticevents, MI & stroke, can be fatal; ↑ risk of serious GI adverse events includingbleeding, ulceration, & perforation of the stomach or intestines; can be fatalUses: *Osteoarthritis & RA, ankylosing spondylitis; acute pain, primary dysmenorrhea;preventive in familial adenomatous polyposis* Action: NSAID; ↓ COX-2pathway Dose: 100–200 mg/d or bid; FAP: 400 mg po bid; ↓ w/hepatic impair;take w/ food/milk Caution: [C/D (3rd tri), ?] w/ renal impair Contra: