Clinician's Pocket Drug Reference 2008

176 ProchlorperazineProchlorperazine (Compazine) Uses: *N/V, agitation, & psychoticdisorders* Action: Phenothiazine; blocks postsynaptic dopaminergic CNS receptorsDose: Adults. Antiemetic: 5–10 mg PO tid–qid or 25 mg PR bid or 5–10 mgdeep IM q4–6h. Antipsychotic: 10–20 mg IM acutely or 5–10 mg PO tid–qid formaint; ↑ doses may be required for antipsychotic effect. Peds. 0.1–0.15mg/kg/dose IM q4–6h or 0.4 mg/kg/24 h PO ÷ tid–qid Caution: [C, +/–] NAG, severeliver/cardiac Dz Contra: Phenothiazine sensitivity, BM suppression; age < 2years old or wt < 9 kg Disp: Tabs 5, 10, 25 mg; SR caps 10, 15 mg; syrup 5 mg/5mL; supp 2.5, 5, 25 mg; inj 5 mg/mL SE: EPS common; Rx w/ diphenhydramineor benztropinePromethazine (Phenergan) Uses: *N/V, motion sickness* Action:Phenothiazine; blocks CNS postsynaptic mesolimbic dopaminergic receptorsDose: Adults. 12.5–50 mg PO, PR, or IM bid–qid PRN. Peds. 0.1–0.5 mg/kg/dosePO or IM q2–6h PRN Caution: [C, +/–] use w/ agents w/ respiratory depressanteffects Contra: Component allergy, NAG, age