Clinician's Pocket Drug Reference 2008

100 Famotidine125–250 mg PO bid; ↓ w/ renal impair Caution: [B, –] Contra: Component sensitivityDisp: Tabs 125, 250, 500 mg SE: Fatigue, dizziness, HA, pruritus, N/DNotes: Best w/in 72 h of initial lesionFamotidine (Pepcid, Pepcid AC) [OTC] Uses: *Short-term Tx ofduodenal ulcer & benign gastric ulcer; maint for duodenal ulcer, hypersecretoryconditions, GERD, & heartburn* Action: H 2 -antagonist; ↓ gastric acid Dose:Adults. Ulcer: 20 mg IV q12h or 20–40 mg PO qhs × 4–8 wk. Hypersecretion:20–160 mg PO q6h. GERD: 20 mg PO bid × 6 wk; maint: 20 mg PO hs. Heartburn:10 mg PO PRN q12h. Peds. 0.5–1 mg/kg/d; ↓ in severe renal insuff Caution:[B, M] Contra: Component sensitivity Disp: Tabs 10, 20, 40 mg; chew tabs10 mg; susp 40 mg/5 mL; gelatin cap 10 mg, inj 10 mg/2 mL SE: Dizziness, HA,constipation, D, thrombocytopenia Notes: Chew tabs contain phenylalanineFelodipine (Plendil) Uses: *HTN & CHF* Action: CCB Dose: 2.5–10 mgPO daily; swallow whole; ↓ in hepatic impair Caution: [C, ?] ↑ effect with azoleantifungals, erythromycin, grapefruit juice Contra: Component sensitivity Disp:ER tabs 2.5, 5, 10 mg SE: Peripheral edema, flushing, tachycardia, HA, gingivalhyperplasia Notes: Follow BP in elderly & w/ hepatic impairFenofibrate (Tricor, Anatra, Lofibra, Lipofen, Triglide) Uses:*Hypertriglyceridemia, hypercholesteremia* Action: ↓ Triglyceride synth Dose:48–145 mg daily; ↓ in renal impair, take w/ meals Caution: [C, ?] Contra: Hepatic/severerenal insuff, primary biliary cirrhosis, unexplained ↑ LFTs, gallbladderDz Disp: Caps 50, 100, 150 mg, Cap (micronized): (Lofibra) 67, 134, 200 mg(Antara) 43, 130 mg; Tabs 54, 160 mg SE: GI disturbances, cholecystitis, arthralgia,myalgia, dizziness, ↑ LFTs Notes: Monitor LFTsFenoldopam (Corlopam) Uses: *Hypertensive emergency* Action:Rapid vasodilator Dose: Initial 0.03–0.1 mcg/kg/min IV inf, titrate q 15 min by 1.6mcg/kg/min to max 0.05–0.1 mcg/kg/min Caution: [B, ?] ↓ BP w/ β-blockers Contra:Allergy to sulfites Disp: Inj 10 mg/mL SE: ↓ BP, edema, facial flushing,N/V/D, atrial flutter/fibrillation, ↑ IOP Notes: Avoid concurrent β-blockersFenoprofen (Nalfon) WARNING: May ↑risk of cardiovascular eventsand GI bleeding Uses: *Arthritis & pain* Action: NSAID Dose: 200–600 mgq4–8h, to 3200 mg/d max; w/ food Caution: [B (D 3rd tri), +/–] CHF, HTN,renal/hepatic impair, Hx PUD Contra: NSAID sensitivity Disp: Caps 200, 300,600 mg SE: GI disturbance, dizziness, HA, rash, edema, renal impair, hepatitisNotes: Swallow wholeFentanyl (Sublimaze) [C-II] Uses: *Short-acting analgesic* in anesthesia& PCA Action: Narcotic analgesic Dose: Adults. 25–100 mcg/kg/dose IV/IMtitrated; Anesthesia: 5–15 mcg/kg; Pain: 200 mcg over 15 min, titrate to effectPeds. 1–2 mcg/kg IV/IM q1–4h titrate; ↓ in renal impair Caution: [B, +] Contra:Paralytic ileus ↑ ICP, resp depression, severe renal/hepatic impair Disp: Inj 0.05mg/mL SE: Sedation, ↓ BP, bradycardia, constipation, N, resp depression, miosisNotes: 0.1 mg fentanyl = 10 mg morphine IM