Clinician's Pocket Drug Reference 2008

Mirtazapine 145intrauterine pregnancies of 2 Disp: Tabs 25, 50, 100 mg SE: Flatulence, D, abd painNotes: Use alone or w/ sulfonylureasMilrinone (Primacor) Uses: *CHF*, calcium antagonist intoxication Action:Phosphodiesterase inhibitor, + inotrope & vasodilator; little chronotropic activityDose: 50 mcg/kg, then 0.375–0.75 mcg/kg/min IV inf; ↓ in renal impairCaution: [C, ?] Contra: Allergy to drug; w/ amrinone Disp: Inj 200 mcg/mL,1 mg/ml SE: Arrhythmias, ↓ BP, HA Notes: Monitor fluids, lytes, BP, HRMineral Oil [OTC] Uses: *Constipation* Action: Lubricant laxative Dose:Adults. 15–45 mL PO PRN. Peds >6 y. 5–25 mL PO q day Caution: [C, ?] N/V,difficulty swallowing, bedridden pts Contra: Colostomy/ileostomy, appendicitis,diverticulitis, UC Disp: Liq [OTC] SE: Lipid pneumonia, anal incontinence, ↓ vitaminabsorptionMinocycline (Solodyn) Uses: *Acne* Action: Tetracycline, bacteriostaticDose: Adult and Peds > 12 yo 1 mg/kg PO daily × 12wk; w/food to ↓ irritationCaution: [C, ?] assoc w/pseudomembranous colitis; w/renal impair Contra: Allergy,women of childbearing potential Disp: Tabs ER 45, 90, 135 SE: D, HA,fever, rash, joint pain, fatigue, dizziness, photosensitivity Notes: Do notcut/crush/chew; keep away from childrenMinoxidil (Loniten, Rogaine) Uses: *Severe HTN; male & female patternbaldness* Action: Peripheral vasodilator; stimulates vertex hair growth Dose:Adults. HTN: 2.5–80 mg PO ÷ daily –bid, max 100mg/day. Topical: (Baldness)Apply bid to area. Peds. 0.2–1 mg/kg/24 h ÷ PO q12–24h, max 50 mg/day; ↓ PO inelderly Caution: [C, +] Contra: Pheochromocytoma, component allergy Disp: Tabs2.5, 5, 10 mg; topical soln (Rogaine) 2%, 5% SE: Pericardial effusion & volumeoverload w/ PO use; hypertrichosis w/chronic use, edema, ECG changes, wgt gainMirtazapine (Remeron, Remeron SolTab) WARNING: Closelymonitor for worsening depression or emergence of suicidality, particularly in pedpts Uses: *Depression* Action: Alpha–2 antagonist antidepressant Dose: 15 mgPO hs, up to 45 mg/d hs Caution: [C, ?] w/ clonidine, CNS depressant use;CYP1A2, CYP3A4 inducers/inhibitors Contra: MAOIs w/in 14 d Disp: Tabs 15,30, 45 mg; rapid dissolving tabs 15, 30, 45 mg SE: Somnolence, ↑ cholesterol,constipation, xerostomia, wgt gain, agranulocytosis Notes: Do not ↑ dose at intervalsof less than 1–2 wk; handle rapid tabs with dry hands, do not cut or chew