Clinician's Pocket Drug Reference 2008

64 Cinacalcetrenal insuff & in elderly Caution: [B, +] Many drug interactions (P-450 system)Contra: Component sensitivity Disp: Tabs 200, 300, 400, 800 mg; liq 300 mg/5mL; inj 300 mg/2 mL SE: Dizziness, HA, agitation, thrombocytopenia, gynecomastiaNotes: 1 h before or 2 h after antacids; avoid EtOHCinacalcet (Sensipar) Uses: *Secondary hyperparathyroidism in CRF; ↑Ca 2+ in parathyroid carcinoma* Action: ↓ PTH by ↑ calcium-sensing receptor sensitivityDose: Secondary hyperparathyroidism: 30 mg PO daily. Parathyroid carcinoma:30 mg PO bid; titrate q2–4wk based on calcium & PTH levels; swallowwhole; take w/ food Caution: [C, ?/–] W/ seizures, adjust w/CYP3A4 inhibitors(Table 11) Disp: Tabs 30, 60, 90 mg SE: N/V/D, myalgia, dizziness, ↓ Ca 2+ Notes:Monitor Ca 2+ , PO -2 4 , PTHCiprofloxacin (Cipro, Cipro XR, Proquin XR) Uses: *Rx lowerresp tract, sinuses, skin & skin structure, bone/joints, & UT Infxns including prostatitis*Action: Quinolone antibiotic; ↓ DNA gyrase. Spectrum: Broad gram(+) &(–) aerobics; little Strep; good Pseudomonas, E. coli, B. fragilis, P. mirabilis, K.pneumoniae, Campylobacter jejuni, or Shigella Dose: Adults. 250–750 mg POq12h; XR 500–1000 mg PO q24h; or 200–400 mg IV q12h; ↓ in renal impair Caution:[C, ?/–] Children 1 mo. 1–2 gtt in ear(s)bid for 7 d Caution: [C, ?/–] Contra: Perforated tympanic membrane, viral Infxnsof the external canal Disp: Susp ciprofloxacin 0.2% & hydrocortisone 1% SE: HA,pruritusCisplatin (Platinol, Platinol AQ) Uses: *Testicular, SCLC, NSCLC,bladder, ovarian, breast, head & neck, & penile CAs; osteosarcoma; ped brain tumors*Action: DNA-binding; denatures double helix; intrastrand cross-linkingDose: 10–20 mg/m 2 /d for 5 d q3wk; 50–120 mg/m 2 q3–4wk; (per protocols); ↓w/renal impair Caution: [D, –] Cumulative renal tox may be severe; Mg 2+ , lytesbefore & w/in 48 h after cisplatin Contra: Platinum-containing compound allergy;↓ BM, hearing impair, preexisting renal insuff Disp: Inj 1 mg/mL SE: AllergicRxns, N/V, nephrotox (↑ w/admin of other nephrotoxic drugs; minimize by NS inf& mannitol diuresis), high-frequency hearing loss in 30%, peripheral “stocking