Clinician's Pocket Drug Reference 2008

Atomoxetine 43Aspirin + Butalbital, Caffeine, & Codeine (Fiorinal + Codeine)[C-III] Uses: Mild *pain*, HA, especially when associated w/ stress Action:Sedative analgesic, narcotic analgesic Dose: 1–2 tabs (caps) PO q4–6h PRN max6/day Caution: [D, ?] Contra: Allergy to ASA and codeine; synd of nasal polyps,angioedema, & bronchospasm to NSAIDs Disp: Cap/tab contains 325 mg ASA, 40mg caffeine, 50 mg of butalbital, 30 mg of codeine SE: Drowsiness, dizziness, GIupset, ulceration, bleeding Notes: D/C 1 wk prior to surgery, avoid/limit ETOHAspirin + Codeine (Empirin No. 3, 4) [C-III] Uses: Mild to *moderatepain* Action: Combined effects of ASA & codeine Dose: Adults. 1–2 tabsPO q4–6h PRN. Peds. ASA 10 mg/kg/dose; codeine 0.5–1 mg/kg/dose q4h Caution:[D, M] Contra: Allergy to ASA/codeine, PUD, bleeding, anticoagulant Rx,children w/ chickenpox or flu Sxs synd of nasal polyps, angioedema, & bronchospasmto NSAIDs Disp: Tabs 325 mg of ASA & codeine (Codeine in No. 3 =30 mg, No. 4 = 60 mg) SE: Drowsiness, dizziness, GI upset, ulceration, bleedingNotes: D/C 1 wk prior to surgery; avoid/limit ETOHAtazanavir (Reyataz) WARNING: Hyperbilirubinemia may requiredrug D/C Uses: *HIV-1 Infxn* Action: Protease inhibitor Dose: 400 mg POdaily w/ food; when given w/ efavirenz 600 mg, administer atazanavir 300 mg + ritonavir100 mg once/d; separate doses from buffered didanosine administration; ↓in hepatic impair Caution: CDC recommends HIV-infected mothers not breastfeed [B, –]; ↑ levels of statins, (avoid lovastatin/simvastatin) sildenafil, antiarrhythmics,warfarin, cyclosporine, TCAs; ↓ w/St. John’s wort, H2 receptor antagonistsContra: w/midazolam, triazolam, ergots, pimozide Disp: Caps 100, 150, 200, 300mg SE: HA, N/V/D, rash, abd pain, DM, photosens, ↑ PR interval Notes: Mayhave less adverse effect on cholesterolAtenolol (Tenormin) Uses: *HTN, angina, MI* Action: β-adrenergic receptorblocker Dose: HTN & angina: 50–100 mg/d PO. AMI: 5 mg IV × 2 over 10min, then 50 mg PO bid if tolerated; ↓ in renal impair; 5 mg IV over 5 min; in 10min, 5 mg slow IV; if tolerated in 10 min, start 50 mg PO, then 50 mg PO BID(ECC 2005) Caution: [D, M] DM, bronchospasm; abrupt D/C can exacerbateangina & ↑ MI risk Contra: Bradycardia, cardiogenic shock, cardiac failure, 2nd-/3rd-degree AV block Disp: Tabs 25, 50, 100 mg; inj 5 mg/10 mL SE: Bradycardia,↓ BP, 2nd-/3rd-degree AV block, dizziness, fatigueAtenolol & Chlorthalidone (Tenoretic) Uses: *HTN* Action:β-adrenergic blockade w/ diuretic Dose: 50–100 mg/d PO; ↓ in renal impair Caution:[D, M] DM, bronchospasm Contra: See atenolol; anuria, sulfonamide crosssensitivityDisp: Tenoretic 50: Atenolol 50 mg/chlorthalidone 25 mg; Tenoretic100: Atenolol 100 mg/chlorthalidone 25 mg SE: Bradycardia, ↓ BP, 2nd- or 3rddegreeAV block, dizziness, fatigue, ↓ K + , photosensAtomoxetine (Strattera) WARNING: Severe liver injury may rarelyoccur; DC w/jaundice or ↑LFT, ↑ frequency of suicidal thinking Uses: *ADHD* Action: Selective norepinephrine reuptake inhibitor Dose: Adults & chil-