Clinician's Pocket Drug Reference 2008

Beclomethasone 47mg PO tid; ↑ q3d to effect; max 80 mg/d. Intrathecal: via implantable pump (seeinsert) Peds. 2–7 y.: 10–15 mg/d ÷ q8h; titrate, max 40 mg/d. >8 y: Max 60 mg/d.IT: via implantable pump; ↓ in renal impair; w/food or milk Caution: [C, +]Epilepsy, neuropsychiatric disturbances; Disp: Tabs 10, 20 mg; IT inj 50 mcg/mL10 mg/20 mL, 10 mg/5 mL SE: Dizziness, drowsiness, insomnia, ataxia, weakness,↓ BPBalsalazide (Colazal) Uses: *Ulcerative colitis* Action: 5-ASA derivative,anti-inflammatory, ↓ leukotriene synth Dose: 2.25 g (3 caps) tid × 8–12 wkCaution: [B, ?] Severe renal/hepatic failure Contra: Mesalamine or salicylates hypersensitivityDisp: Caps 750 mg SE: Dizziness, HA, N, agranulocytosis, pancytopenia,renal impair, allergic Rxns Notes: Daily dose of 6.75 g = to 2.4 gmesalamineBasiliximab (Simulect) WARNING: Administer only under the supervisionof a physician experienced in immunosuppression therapy in an appropriatefacility Uses: *Prevent acute transplant rejection* Action: IL-2 receptor antagonistsDose: Adults. 20 mg IV 2 h before transplant, then 20 mg IV 4 d post. Peds.12 mg/m 2 ↑ to max of 20 mg 2 h prior to transplant; same dose IV 4 d post Caution:[B, ?/–] avoid w/other immunosuppressants Contra: Hypersensitivity tomurine proteins Disp: Inj: powder for recons 10, 20 mg SE: Edema, HTN, HA,dizziness, fever, pain, Infxn, GI effects, electrolyte disturbances Notes: Amurine/human MoAbBCG [Bacillus Calmette-Guérin] (TheraCys, Tice BCG) Uses:*Bladder carcinoma (superficial),* TB prophylaxis Action: ImmunomodulatorDose: Bladder CA, 1 vial prepared & instilled in bladder for 2 h. Repeat once/wkfor 6 wk; then 1 treatment at 3, 6, 12, 18, & 24 mo after initial therapy Caution:[C, ?] Asthma Contra: Immunosuppression, UTI, steroid use, acute illness, feverof unknown origin, w/traumatic catheterization or UTI Disp: Inj powder for recons81 mg (10.5 ± 8.7 × 108 CFU vial) (TheraCys), 50 mg (1–8 × 10 8 CFU/vial) (TiceBCG) SE: Intravesical: Hematuria, urinary frequency, dysuria, bacterial UTI, rareBCG sepsis Notes: Routine US adult BCG immunization not rec; occasionallyused in high-risk children who are PPD(–) & cannot take INH, dispose/void in toiletwith chlorine bleachBecaplermin (Regranex Gel) Uses: Adjunct to local wound carew/ *diabetic foot ulcers* Action: Recombinant PDGF, enhances granulation tissueDose: Based on lesion; 11/3-in. ribbon from 2-g tube, 2/3-in. ribbon from 15-gtube/in. × in 2 of ulcer; apply & cover w/moist gauze; rinse after 12 h; do not reapply;repeat in 12 h Caution: [C, ?] Contra: Neoplasm/or active site Infxn Disp:0.01% gel in 2-, 15-g tubes SE: Erythema, local pain Notes: Use w/ good woundcare; wound must be vascularizedBeclomethasone (Beconase) Uses: *Allergic rhinitis* refractory to antihistamines& decongestants; *nasal polyps* Action: Inhaled steroid Dose:Adults & Peds 6–12 y. Aqueous inhal: 1–2 sprays/nostril twice daily Caution: