Clinician's Pocket Drug Reference 2008

Argatroban 41Antithymocyte Globulin (See Lymphocyte Immune Globulin,page 136)Apomorphine (Apokyn) WARNING: Do not administer IV Uses:*Acute, intermittent hypomobility (“off”) episodes of Parkinson Dz* Action:Dopamine agonist Dose: Adults. 0.2-mL SQ test dose under medical supervision;if BP OK, initial 0.2 mL (2 mg) SQ during “off” periods; only 1 dose per “off” period;titrate dose; 0.6 mL (6 mg)max single doses; use w/antiemetic; ↓ in renal impairCaution: [C, +/–] Avoid EtOH; antihypertensives, vasodilators, cardio orcerebrovascular Dz, hepatic impair Contra: 5HT3 antagonists, sulfite allergyDisp: Inj 10 mg/mL, 3-mL pen cartridges; 2-mL amp SE: Emesis, syncope, QTprolongation, orthostatic ↓ BP, somnolence, ischemia, injection site Rxn, abuse potential,dyskinesia, fibrotic conditions, priapism Notes: Daytime somnolence maylimit activities; trimethobenzamide 300 mg tid PO or other non-5HT3 antagonistantiemetic given 3 d prior to & up to 2 mo following initiationApraclonidine (Iopidine) Uses: *Glaucoma, postop intraocular HTN*Action: α 2 -adrenergic agonist Dose: 1–2 gtt of 0.5% tid; 1 gtt before and after surgicalprocedure Caution: [C, ?] Contra: w/ MAOI Disp: 0.5, 1% soln SE: Ocularirritation, lethargy, xerostomiaAprepitant (Emend) Uses *Prevents N/V assoc w/ emetogenic CAchemo (eg, cisplatin) (use in combo w/ other antiemetics)* Action: SubstanceP/neurokinin 1(NK 1 ) receptor antagonist Dose: 125 mg PO day 1, 1 h beforechemo, then 80 mg PO q AM days 2 & 3 Caution: [B, ?/–]; substrate & modCYP3A4 inhibitor; CYP2C9 inducer (Table 11) Contra: Use w/ pimozide, Disp:Caps 40, 80, 125 mg SE: Fatigue, asthenia, hiccups Notes: ↓ effect OCP andwarfarinAprotinin (Trasylol) WARNING: May cause fatal anaphylactic Rxns Uses:*↓ loss during CABG* Action: Protease inhib, antifibrinolytic Dose: 1-mL IV testdose; High dose: 2 million KIU load, 2 million KIU to prime pump, then 500,000KIU/h until surgery ends; Low dose: 1 million KIU load, 1 million KIU to primepump, then 250,000 KIU/h until surgery ends; 7 million KIU max total Caution: [B,?] Thromboembolic Dz requiring anticoagulants/blood factor administration Contra:Previous use