Clinician's Pocket Drug Reference 2008

182 RimantadineRimantadine (Flumadine) Uses: *Prophylaxis & Rx of influenza Aviral Infxns* Action: Antiviral Dose: Adults & Peds > 9 y. 100 mg PO bid. Peds1–9 y. 5 mg/kg/d PO, 150 mg/d max; daily w/ severe renal/hepatic impair & elderly;initiate w/in 48 h of Sx onset Caution: [C, –] w/ cimetidine; avoidw/PRG,breast-feeding Contra: Component & amantadine allergy Disp: Tabs 100mg; syrup 50 mg/5 mL SE: Orthostatic ↓ BP, edema, dizziness, GI upset, ↓ Szthreshold. Note: See CDC (MMWR) for current Influenza A guidelinesRimexolone (Vexol Ophthalmic) Uses: *Postop inflammation &uveitis* Action: Steroid Dose: Adults & Peds > 2 y. Uveitis: 1–2 gtt/h daytime &q2h at night, taper to 1 gtt q4h; Postop: 1–2 gtt qid ≤2 wk Caution: [C, ?/–] OcularInfxns Disp: Susp 1% SE: Blurred vision, local irritation Notes: Taper doseRisedronate (Actonel w/calcium) Uses: *Paget Dz; Rx/prevent glucocorticoid-induced/postmenopausalosteoporosis* Action: Bisphosphonate; ↓ osteoclast-mediatedbone resorption Dose: Paget Dz: 30 mg/d PO for 2 mo. OsteoporosisRx/prevention: 5 mg daily or 35 mg qwk; 30 min before 1st food/drink of the day;stay upright for at least 30 min after Caution: [C, ?/–] Ca supls & antacids ↓ absorptionContra: Component allergy, ↓ Ca 2+ , esophageal abnormalities, unable tostand/sit for 30 min, CrCl < 30 mL/min Disp: Tabs 5, 30, 35, 75 mg; Risedronate 35mg (4 tabs)/calcium carbonate 1250 mg (24 tabs) SE: HA, D, abd pain, arthralgia;flulike Sxs, rash, esophagitis, bone pain Notes: Monitor LFT, Ca 2+ , PO 3+ , K +Risperidone, parenteral (Risperdal Constra) WARNING: Notapproved for dementia-related psychosis; ↑ mortality risk in elderly dementia ptson atypical antipsychotics; most deaths due to CV or infectious events Uses:Schizophrenia Action: Benzisaxazole antipsychotic Dose: 25 mg q 2 weeks IMmay ↑ to max 50 mg q2 weeks; w/renal/hepatic impair start PO Risperidal 0.5 mgPO bid × 1 wk titrate weekly Caution: [C, –], ↑ BP w/ antihypertensives, clozapineContra: Component allergy Disp: Inj 25, 37.5, 50 mg/vial SE: See risperidoneNote: Long-acting injectionRisperidone, oral (Risperdal, Risperidal M-Tab) WARNING: ↑mortality in elderly with dementia-related psychosis Uses: *Psychotic disorders(schizophrenia),* dementia of the elderly, bipolar disorder, mania, Tourette disorder,autism Action: Benzisoxazole antipsychotic Dose: Adults. 0.5–6 mg PO bid;M-Tab 1–6 mg/d start 1–2 mg/day, titrate q 3–7 days Peds/Adolescents. 0.25 mgPO bid, ↑ q5–7d; ↓ start dose w/elderly, renal/hepatic impair Caution: [C, –], ↑BP w/ antihypertensives, clozapine Contra: Component allergy Disp: Tabs 0.25,0.5, 1, 2, 3, 4mg; soln 1 mg/mL, M-Tab (orally disintegrating) tabs 0.5, 1, 2, 3, 4mg SE: Orthostatic ↓ BP, EPS w/ high dose, tachycardia, arrhythmias, sedation,dystonias, neuroleptic malignant synd, sexual dysfunction, constipation, xerostomia,blood dyscrasias, cholestatic jaundice, wgt Notes: Several weeks for effectRitonavir (Norvir) WARNING: Life-threatening adverse events whenused with certain nonsedating antihistamines, sedative hypnotics, antiarrhythmics,