Clinician's Pocket Drug Reference 2008

240 TablesTABLE 11Cytochrome P-450 Isoenzymes and Common DrugsThey Metabolize, Inhibit, and Induce aSubstrates:Inhibitors:Inducers:Substrates:Inhibitors:Inducers:Substrates:Inhibitors:Inducers:Substrates:Inhibitors:Inducers:Substrates:CYP1A2Acetaminophen, caffeine, clozapine, imipramine, theophylline,propranololMost fluoroquinolone antibiotics, fluvoxamine, cimetidineTobacco smoking, charcoal-broiled foods, cruciferous vegetables,omeprazoleCYP2C9Most NSAIDs (including COX-2), warfarin, phenytoinFluconazoleBarbiturates, rifampinCYP2C19Diazepam, lansoprazole, omeprazole, phenytoin, pantoprazoleOmeprazole, isoniazid, ketoconazoleBarbiturates, rifampinCYP2D6Most -blockers, codeine, clomipramine, clozapine,codeine, encainide, flecainide, fluoxetine, haloperidol,hydrocodone, 4-methoxy-amphetamine, metoprolol,mexiletine, oxycodone, paroxetine, propafenone,propoxyphene, risperidone, selegiline (deprenyl),thioridazine, most tricyclic antidepressants, timololFluoxetine, haloperidol, paroxetine, quinidineUnknownCYP3AAnticholinergics: Darifenacin, oxybutynin, solifenacin,tolterodineBenzodiazepines: Alprazolam, midazolam, triazolamCa channel blockers: Diltiazem, felodipine, nimodipine,nifedipine, nisoldipine, verapamil(continued)