Clinician's Pocket Drug Reference 2008

62 ChlorpheniramineChlorpheniramine (Chlor-Trimeton, others) [OTC] Uses: *Allergicrhinitis* common cold Action: Antihistamine Dose: Adults. 4 mg PO q4–6hor 8–12 mg PO bid of SR Peds. 0.35 mg/kg/24 h PO ÷ q4–6h or 0.2 mg/kg/24 h SRCaution: [B, ?/–] BOO; NAG; hepatic insuff Contra: Allergy Disp: Tabs 4 mg;chew tabs 2 mg; SR tabs 8, 12 mg SE: Anticholinergic SE & sedation common,postural ↓ BP, QT changes, extrapyramidal Rxns, photosens Notes: Do notcut/crush/chew ER forms; recent deaths in < 2 y. assoc w/cough and cold meds(MMWR 2007 56(01):1-4)Chlorpromazine (Thorazine) Uses: *Psychotic disorders, N/V,* apprehension,intractable hiccups Action: Phenothiazine antipsychotic; antiemetic Dose:Adults. Psychosis: 10–25 mg PO bid-tid (usual 30–800 mg/d in ÷ doses). Severe Sxs:25 mg IM/IV initial; may repeat in 1–4 h; then 25–50 mg PO or PR tid. Hiccups:25–50 mg PO bid-tid. Children >6 mo. Psychosis & N/V: 0.5–1 mg/kg/dose PO q4–6hor IM/IV q6–8h; Caution: [C, ?/–] Safety in children