Clinician's Pocket Drug Reference 2008

174 Pramipexole(eg, diuretic use) Action: K + supl Dose: Adults. 20–100 mEq/d PO ÷ daily–bid; IV10–20 mEq/h, max 40 mEq/h & 150 mEq/d (monitor K + levels frequently w/ highdoseIV). Peds. Calculate K + deficit; 1–3 mEq/kg/d PO ÷ daily–qid; IV max dose0.5–1 mEq/kg/h Caution: [A, +] Renal insuff, use w/ NSAIDs & ACE inhibitorsContra: ↑ K + Disp: PO forms (Table 7); inj SE: GI irritation; bradycardia, ↑ K + ,heart block Notes: Mix powder & liq w/ beverage (unsalted tomato juice, etc); followK + ; Cl – salt OK w/ alkalosis; w/ acidosis use acetate, bicarbonate, citrate, orgluconate saltPramipexole (Mirapex) Uses: *Parkinson Dz* Action: Dopamine agonistDose: 1.5–4.5 mg/d PO, initial 0.375 mg/d in 3 ÷ doses; titrate slowly Caution:[C, ?/–] ↓ renal impair Contra: Component allergy Disp: Tabs 0.125, 0.25,0.5, 1, 1.5 mg SE: Postural ↓ BP, asthenia, somnolence, abnormal dreams, GIupset, EPSPramoxine (Anusol Ointment, ProctoFoam-NS, others)Uses: *Relief of pain & itching from hemorrhoids, anorectal surgery*; topical forburns & dermatosis Action: Topical anesthetic Dose: Apply freely to anal area q3hCaution: [C, ?] Disp: [OTC] All 1%; foam (Proctofoam-NS), cream, oint, lotion,gel, pads, spray SE: Contact dermatitis, mucosal thinning w/ chronic usePramoxine + Hydrocortisone (Enzone, Proctofoam-HC)Uses: *Relief of pain & itching from hemorrhoids* Action: Topical anesthetic,anti-inflammatory Dose: Apply freely to anal area tid–qid Caution: [C, ?/–] Disp:Cream pramoxine 1% acetate 0.5/1%; foam pramoxine 1% hydrocortisone 1%; lotionpramoxine 1% hydrocortisone 0.25/1/2.5%, pramoxine 2.5% & hydrocortisone1% SE: Contact dermatitis, mucosal thinning with chronic usePravastatin (Pravachol) Uses: * ↓ Cholesterol* Action: HMG-CoA reductaseinhibitor Dose: 10–80 mg PO hs; ↓ in significant renal/hepatic impairCaution: [X –] w/ gemfibrozil Contra: Liver Dz or persistent LFT ↑ Disp: Tabs10, 20, 40, 80 mg SE: Use caution w/ concurrent gemfibrozil; HA, GI upset, hepatitis,myopathy, renal failurePrazosin (Minipress) Uses: * HTN* Action: Peripherally acting α-adrenergicblocker Dose: Adults. 1 mg PO tid; can ↑ to 20 mg/d max PRN. Peds.0.05–0.1 mg/kg/day in 3 div doses; max 0.5 mg. kg/day Caution: [C, ?] Contra:Component allergy, concurrent use of PDE-5 inhibitors Disp: Caps 1, 2, 5 mg;Tabs ER 2.5, 5 mg ER SE: Dizziness, edema, palpitations, fatigue, GI upset Notes:Can cause orthostatic ↓ BP, take the 1st dose hs; tolerance develops to this effect;tachyphylaxis may resultPrednisolone [See Steroids page 191 and Table 3, page227]Prednisone [See Steroids page 191 and Table 3, page227]Pregabalin (Lyrica) Uses: *DM peripheral neuropathy pain; postherpeticneuralgia; fibromyalgia; adjunct w/adult partial onset seizures* Action: Nerve