produção de micropartículas e nanopartículas poliméricas ... - UFRJ

Abstract of Thesis presented to COPPE/UFRJ as a partial fulfillment of the
requirements for the degree of Doctor of Science (D.Sc.)
PRODUCTION OF POLYMERIC MICROPARTICULES AND NANOPARTICULES
USING HETEROGENEOUS POLYMERIZATION SYSTEM FOR BIOMEDICAL
APPLICATION
Marco Antonio Monteiro de Oliveira
October/2011
Advisors: José Carlos Costa da Silva Pinto
Márcio Nele de Souza
Department: Chemical Engineering
In this study we report the use of different polymerization systems to produce
polymers to be used in biomedical applications. In a first moment, polymer
microparticles containing drugs were produced for use as embolic or chemoembolic
agents. The polymer microparticles were synthesized by suspension polymerization
with in situ incorporation of drugs during polymerization reaction. Experimental results
showed that the final properties of the obtained polymers depend on the type of drug,
amount and strategy of drug incorporation. In a second moment, biodegradable
hydrogel nanoparticles were synthesized for use as nanocarriers for bioactive molecules.
In order to achieve this objective, an operation strategy was developed to synthesize
biodegradable hydrogel nanoparticles via RAFT inverse miniemulsion polymerization
with well-defined molecular architecture and characteristics that guarantee the potential
application of the biodegradable hydrogel nanoparticles for the controlled release of
bioactive molecules.
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