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RESEARCH & BioAssay HTS Biological Assay and High Throughput Screening BioAssay HTS BioAssay HTS provides scientists with an effective way of managing test results for biological and other kinds of experiments intended to assess the efficacy of compounds. Suitable for both plate-based high throughput screening assays and smaller-scale lead optimization experiments, BioAssay HTS provides researchers with simple tools for setting up their models in a database, uploading data, automating calculations and reporting on their findings. User Friendly Assay Management Even for the most basic protein assays, the independent and dependent variables used by the biologist to quantify efficacy can vary substantially from assay to assay. The underlying requirement that follows from this variability is for a flexible data management system that can adapt quickly to different assays and biological models. With BioAssay HTS, researchers or IT support staff simply define the observables and calculations that make up the assay. The database does the rest. Users can set up unlimited levels of drill-down. This allows users, for example, to click an IC50 and see a graph of percent inhibition versus concentration. Click again, and the software displays the original triplicate results, with outliers marked. The software even supports complex in vivo models. Automated Curve Fitting & Data Analysis Flexible Assay Definition Tools
DISCOVERY •Effectively manages data from complex biological assays involved with lead optimization • Adapts quickly and flexibly to different assays and biological models • Closely integrated with Microsoft Excel, ChemOffice and ChemDraw Easily Manage Large Volumes of Data BioAssay HTS offers an easy way to capture large volumes of data from automated laboratory equipment and store it securely in Oracle. Scheduled data import means you can set up an import template once, and all future data will appear in the system as it is gathered. BioAssay HTS contains a complete plate inventory system that tracks plates and compound groups across plates. It easily manages daughter plate creation, barcoding, and freeze/thaw cycle tracking. Since it is integrated with your assay data, you can instantly view compound information and visualize results plate-wise to detect anomalies before they become a problem. Automated Calculations & Curve Fitting Once the database is configured for an assay, calculations are performed automatically whenever new data is entered or imported. Calculations can be quite complex, built from multi-step procedures. For an IC50 assay in triplicate, the software can average your triplicate results, take control values into account, and perform a sigmoidal dose-response curve fit according to your specifications. It is now as easy to do for 10,000 compounds as it is for ten. Find Structure-Activity Relationships Users can visualize data for multiple assays with BioSAR Browser, which is specifically designed for viewing structures and alphanumerics side-by-side. Other components of the ChemOffice product line provide additional ways to analyze structural and biological data and perform structure searches. Both ChemFinder and ChemOffice WebServer make it easy to create customized forms for viewing data. Users can export data to Excel or Spotfire for further analysis and reporting. EMAIL info@cambridgesoft.com WWW www.cambridgesoft.com TEL 1 800 315–7300 INT’L 1 617 588–9300 FAX 1 617 588–9390 MAIL CambridgeSoft Corporation 100 CambridgePark Drive Cambridge, MA 02140 USA ChemOffice, ChemDraw, Chem3D, ChemFinder & ChemInfo are trademarks of CambridgeSoft ©2002. All other trademarks are the property of their respective holders. All specifications subject to change without notice.
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ChemOffice.Com ® ChemOffice ® Ent
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License Information ChemOffice, Che
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· Licensed users of ChemOffice Ent
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computer, except as provided below.
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